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Maternal immunization as a strategy to decrease susceptibility to infection in newborn infants

Maternal immunization as a strategy to decrease susceptibility to infection in newborn infants
Maternal immunization as a strategy to decrease susceptibility to infection in newborn infants
Purpose of Review: Following on from the success of maternal tetanus vaccination, recent research has shown that other vaccines given in pregnancy can protect against vaccine-preventable infections in early infancy. This review will outline these recent developments and highlight the impact on current clinical practice. RECENT FINDINGS: Maternal immunization provides protection to the newborn through the transfer of vaccine-induced IgG across the placenta, a process that is affected by multiple variables. The safety of newly recommended maternal vaccines has been further tested in recent studies. Maternal vaccination against influenza and pertussis is recommended in the United Kingdom and United States, with new studies indicating their efficacy. A number of additional maternal vaccines are also in the pipeline, which could be used to combat neonatal infection. Recent research findings have highlighted some of the reasons for the poor uptake of current recommendations among pregnant women. SUMMARY: Tetanus, influenza and pertussis vaccines are now recommended for use during pregnancy, with new vaccines, such as group B streptococcus and respiratory syncytial virus, being developed to prevent important neonatal infections in the future.
maternal immunization, neonatal infection, pregnancy, vaccination
0951-7375
248-253
Lindsey, Benjamin
006d4ed8-212b-4913-9d4f-a1f957949cfa
Kampmann, Beate
4490f5e3-318c-4074-bf69-4a23bd5ec100
Jones, Christine
48229079-8b58-4dcb-8374-d9481fe7b426
Lindsey, Benjamin
006d4ed8-212b-4913-9d4f-a1f957949cfa
Kampmann, Beate
4490f5e3-318c-4074-bf69-4a23bd5ec100
Jones, Christine
48229079-8b58-4dcb-8374-d9481fe7b426

Lindsey, Benjamin, Kampmann, Beate and Jones, Christine (2013) Maternal immunization as a strategy to decrease susceptibility to infection in newborn infants. Current Opinion in Infectious Diseases, 26 (3), 248-253. (doi:10.1097/QCO.0b013e3283607a58).

Record type: Review

Abstract

Purpose of Review: Following on from the success of maternal tetanus vaccination, recent research has shown that other vaccines given in pregnancy can protect against vaccine-preventable infections in early infancy. This review will outline these recent developments and highlight the impact on current clinical practice. RECENT FINDINGS: Maternal immunization provides protection to the newborn through the transfer of vaccine-induced IgG across the placenta, a process that is affected by multiple variables. The safety of newly recommended maternal vaccines has been further tested in recent studies. Maternal vaccination against influenza and pertussis is recommended in the United Kingdom and United States, with new studies indicating their efficacy. A number of additional maternal vaccines are also in the pipeline, which could be used to combat neonatal infection. Recent research findings have highlighted some of the reasons for the poor uptake of current recommendations among pregnant women. SUMMARY: Tetanus, influenza and pertussis vaccines are now recommended for use during pregnancy, with new vaccines, such as group B streptococcus and respiratory syncytial virus, being developed to prevent important neonatal infections in the future.

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More information

Published date: June 2013
Keywords: maternal immunization, neonatal infection, pregnancy, vaccination

Identifiers

Local EPrints ID: 474852
URI: http://eprints.soton.ac.uk/id/eprint/474852
ISSN: 0951-7375
PURE UUID: e7a6bfc8-7487-4026-b000-3d97cc620826
ORCID for Christine Jones: ORCID iD orcid.org/0000-0003-1523-2368

Catalogue record

Date deposited: 03 Mar 2023 17:49
Last modified: 06 Jun 2024 01:58

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Contributors

Author: Benjamin Lindsey
Author: Beate Kampmann
Author: Christine Jones ORCID iD

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