Drugs conjugated with hexose phosphate and methods of making and using same
Drugs conjugated with hexose phosphate and methods of making and using same
A drug conjugate, composition, and use for manufacture of a medicament for delivering active antimicrobials based on existing antibiotics through a hexose phosphate transporter (UhpT) by conjugating the antimicrobials with non-metabolizable hexose phosphates. Coadministration antibiotics with non-metabolizable hexose phosphates as antimicrobials is also disclosed. Non-metabolizable hexose phosphates can constitutively and strongly induce expression of UhpT which significantly improves the efficacy and/or antimicrobial spectrum of antibiotics. This drug conjugate, composition and use will permit reuse of many FDA approved antibiotics that have been abandoned or fallen into disuse due to their current low efficacy and/or resistance to these antibiotics by pathogens.
WO2022-072425A1
World Intellectual Property Organization
4 July 2022
Park, Joo Youn
3c332dc4-398d-434c-a5d0-df98be528ec7
Seo, Keun Seok
e9e75d0e-9a2a-4d42-a02c-c75195cade3e
Lee, Seung Seo
ee34fa26-5fb6-48c8-80c2-1f13ec4ccceb
Park, Joo Youn, Seo, Keun Seok and Lee, Seung Seo
(Inventors)
(2022)
Drugs conjugated with hexose phosphate and methods of making and using same.
WO2022-072425A1.
Abstract
A drug conjugate, composition, and use for manufacture of a medicament for delivering active antimicrobials based on existing antibiotics through a hexose phosphate transporter (UhpT) by conjugating the antimicrobials with non-metabolizable hexose phosphates. Coadministration antibiotics with non-metabolizable hexose phosphates as antimicrobials is also disclosed. Non-metabolizable hexose phosphates can constitutively and strongly induce expression of UhpT which significantly improves the efficacy and/or antimicrobial spectrum of antibiotics. This drug conjugate, composition and use will permit reuse of many FDA approved antibiotics that have been abandoned or fallen into disuse due to their current low efficacy and/or resistance to these antibiotics by pathogens.
More information
Published date: 4 July 2022
Identifiers
Local EPrints ID: 474894
URI: http://eprints.soton.ac.uk/id/eprint/474894
PURE UUID: 127b2373-95c7-42b3-8d45-f5656a711b55
Catalogue record
Date deposited: 06 Mar 2023 17:55
Last modified: 17 Mar 2024 03:31
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Contributors
Inventor:
Joo Youn Park
Inventor:
Keun Seok Seo
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