Global substrate mapping and targeted ablation with novel gold-tip catheter in De Novo persistent AF
Global substrate mapping and targeted ablation with novel gold-tip catheter in De Novo persistent AF
Results from catheter ablation for persistent AF are suboptimal, with no strategy other than pulmonary vein isolation showing clear benefit. Recently employed empirical strategies beyond pulmonary vein isolation involve widespread atrial ablation in all patients and do not take into account patient-specific differences in AF mechanisms or phenotype. Charge density mapping using the non-contact AcQMap system (Acutus Medical) allows visualisation of whole-chamber activation during AF and reveals localised patterns of complex activation thought to represent important mechanisms for AF maintenance that can be targeted with focal ablation. In this review, the authors outline the fundamentals of this technology, the initial data exploring the mechanistic role of activation patterns seen and the application to ablation of persistent AF.
atrial fibrillation, charge density, core-to-boundary ablation, Non-contact mapping
Pope, Michael T.B.
4e7343b7-a8c4-4ce4-a813-ff0d894b0f92
Betts, Timothy R.
a9d90073-a54a-478c-81f0-39ecc5234047
21 May 2022
Pope, Michael T.B.
4e7343b7-a8c4-4ce4-a813-ff0d894b0f92
Betts, Timothy R.
a9d90073-a54a-478c-81f0-39ecc5234047
Pope, Michael T.B. and Betts, Timothy R.
(2022)
Global substrate mapping and targeted ablation with novel gold-tip catheter in De Novo persistent AF.
Arrhythmia and Electrophysiology Review, 11, [e06].
(doi:10.15420/aer.2021.64).
Abstract
Results from catheter ablation for persistent AF are suboptimal, with no strategy other than pulmonary vein isolation showing clear benefit. Recently employed empirical strategies beyond pulmonary vein isolation involve widespread atrial ablation in all patients and do not take into account patient-specific differences in AF mechanisms or phenotype. Charge density mapping using the non-contact AcQMap system (Acutus Medical) allows visualisation of whole-chamber activation during AF and reveals localised patterns of complex activation thought to represent important mechanisms for AF maintenance that can be targeted with focal ablation. In this review, the authors outline the fundamentals of this technology, the initial data exploring the mechanistic role of activation patterns seen and the application to ablation of persistent AF.
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Accepted/In Press date: 14 February 2022
Published date: 21 May 2022
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Publisher Copyright:
© 2022 Radcliffe Group Ltd. All rights reserved.
Keywords:
atrial fibrillation, charge density, core-to-boundary ablation, Non-contact mapping
Identifiers
Local EPrints ID: 474961
URI: http://eprints.soton.ac.uk/id/eprint/474961
ISSN: 2050-3369
PURE UUID: 6d30281e-eab2-459a-bb3a-13e0e9278277
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Date deposited: 07 Mar 2023 17:47
Last modified: 17 Mar 2024 00:37
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Contributors
Author:
Michael T.B. Pope
Author:
Timothy R. Betts
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