The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging
The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging
Obesity is an escalating global health problem associated with both an increased risk of death and an increased risk of cardiovascular events. Our goal was to use magnetic resonance imaging (MRI) to determine the effect of obesity and weight loss, in the absence of the traditional cardiovascular risk factors, on aortic pulse wave velocity (PWV) a reliable, reproducible, and accurate clinical measure of aortic stiffness linked to increased mortality. Fifty obese (BMI 38.3 ± 6.8 kg/m2) and eighteen normal-weight controls (BMI 22.0 ± 1.7 kg/m2) with no identifiable cardiovascular risk factors underwent vascular MRI to assess PWV between the ascending aorta at the level of the pulmonary artery and the abdominal aorta (AA). Twenty-eight subjects underwent repeat imaging after a 1-year period of weight loss. Both groups were well matched for age, systolic blood pressure, fasting glucose, and total cholesterol. Obesity was associated with a 14% increase in PWV (P = 0.021), and with elevated C-reactive protein (CRP) (P < 0.01) and leptin levels (P < 0.001) factors known to cause increase arterial stiffness. Weight loss (average 50% excess weight) was associated with a 14% improvement in PWV (P = 0.03), and with reductions in serum leptin levels (P < 0.01). Obesity, in the absence of the traditional cardiovascular risk factors, is associated with increased aortic PWV, a noninvasive clinical measure of aortic stiffness independently predictive of cardiovascular mortality. Significant weight loss results in improvements in aortic PWV. This may provide a potential link between both obesity and increased mortality, and the reduction in mortality that occurs with weight loss.
2311-2316
Byrne, James
e3d5b8fe-1b69-441c-a173-e084fe5372a6
Rider, Oliver J.
fbbf9870-f09e-4250-8aa3-4ff3eb30c30d
Tayal, Upasana
357686a7-011f-40d8-b25c-0f552af63b09
1 December 2010
Byrne, James
e3d5b8fe-1b69-441c-a173-e084fe5372a6
Rider, Oliver J.
fbbf9870-f09e-4250-8aa3-4ff3eb30c30d
Tayal, Upasana
357686a7-011f-40d8-b25c-0f552af63b09
Byrne, James, Rider, Oliver J. and Tayal, Upasana
(2010)
The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging.
Obesity, 18 (12), .
(doi:10.1038/oby.2010.64).
Abstract
Obesity is an escalating global health problem associated with both an increased risk of death and an increased risk of cardiovascular events. Our goal was to use magnetic resonance imaging (MRI) to determine the effect of obesity and weight loss, in the absence of the traditional cardiovascular risk factors, on aortic pulse wave velocity (PWV) a reliable, reproducible, and accurate clinical measure of aortic stiffness linked to increased mortality. Fifty obese (BMI 38.3 ± 6.8 kg/m2) and eighteen normal-weight controls (BMI 22.0 ± 1.7 kg/m2) with no identifiable cardiovascular risk factors underwent vascular MRI to assess PWV between the ascending aorta at the level of the pulmonary artery and the abdominal aorta (AA). Twenty-eight subjects underwent repeat imaging after a 1-year period of weight loss. Both groups were well matched for age, systolic blood pressure, fasting glucose, and total cholesterol. Obesity was associated with a 14% increase in PWV (P = 0.021), and with elevated C-reactive protein (CRP) (P < 0.01) and leptin levels (P < 0.001) factors known to cause increase arterial stiffness. Weight loss (average 50% excess weight) was associated with a 14% improvement in PWV (P = 0.03), and with reductions in serum leptin levels (P < 0.01). Obesity, in the absence of the traditional cardiovascular risk factors, is associated with increased aortic PWV, a noninvasive clinical measure of aortic stiffness independently predictive of cardiovascular mortality. Significant weight loss results in improvements in aortic PWV. This may provide a potential link between both obesity and increased mortality, and the reduction in mortality that occurs with weight loss.
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Published date: 1 December 2010
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Local EPrints ID: 475026
URI: http://eprints.soton.ac.uk/id/eprint/475026
ISSN: 1930-7381
PURE UUID: 821d362b-f814-4042-8315-5c80cb02888f
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Date deposited: 08 Mar 2023 17:57
Last modified: 17 Mar 2024 00:13
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Author:
James Byrne
Author:
Oliver J. Rider
Author:
Upasana Tayal
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