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Advances in diagnosis and management of childhood osteoporosis

Advances in diagnosis and management of childhood osteoporosis
Advances in diagnosis and management of childhood osteoporosis
Childhood osteoporosis leads to increased propensity to fracture, and thus is an important cause of morbidity, pain and healthcare utilisation. Osteoporosis in children may be caused by a primary bone defect or secondary to an underlying medical condition and/or its treatment. Primary osteoporosis is rare, but there is an increasing number of children with risk factors for secondary osteoporosis. Therefore it is imperative that all paediatricians are aware of the diagnostic criteria and baseline investigations for childhood osteoporosis to enable timely referral to a specialist in paediatric bone health. This review will discuss the approach to diagnosis, investigation and management of childhood osteoporosis, with particular consideration to advances in molecular diagnosis of primary bone disorders, and current and emerging therapies for fracture reduction.
Child, Humans, Osteoporosis/diagnosis, Fractures, Bone, Bone and Bones, Risk Factors, Bone Density
1308-5727
370-384
Lim, David B. N.
b7d831d9-d090-4186-8007-6f299a0e3907
Moon, Rebecca J.
16ba3d3f-010f-4b11-a9c2-635979a27f4a
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9
Lim, David B. N.
b7d831d9-d090-4186-8007-6f299a0e3907
Moon, Rebecca J.
16ba3d3f-010f-4b11-a9c2-635979a27f4a
Davies, Justin H.
9f18fcad-f488-4c72-ac23-c154995443a9

Lim, David B. N., Moon, Rebecca J. and Davies, Justin H. (2022) Advances in diagnosis and management of childhood osteoporosis. Journal of Clinical Research in Pediatric Endocrinology, 14 (4), 370-384. (doi:10.4274/jcrpe.galenos.2022.2022-8-3).

Record type: Review

Abstract

Childhood osteoporosis leads to increased propensity to fracture, and thus is an important cause of morbidity, pain and healthcare utilisation. Osteoporosis in children may be caused by a primary bone defect or secondary to an underlying medical condition and/or its treatment. Primary osteoporosis is rare, but there is an increasing number of children with risk factors for secondary osteoporosis. Therefore it is imperative that all paediatricians are aware of the diagnostic criteria and baseline investigations for childhood osteoporosis to enable timely referral to a specialist in paediatric bone health. This review will discuss the approach to diagnosis, investigation and management of childhood osteoporosis, with particular consideration to advances in molecular diagnosis of primary bone disorders, and current and emerging therapies for fracture reduction.

Text
FD JJ 1. JCRPE-2022-8-3 - Accepted Manuscript
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More information

Accepted/In Press date: 18 August 2022
e-pub ahead of print date: 1 December 2022
Keywords: Child, Humans, Osteoporosis/diagnosis, Fractures, Bone, Bone and Bones, Risk Factors, Bone Density

Identifiers

Local EPrints ID: 475074
URI: http://eprints.soton.ac.uk/id/eprint/475074
ISSN: 1308-5727
PURE UUID: 44fe570b-6283-4007-9e8c-c6a754693876

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Date deposited: 09 Mar 2023 19:02
Last modified: 17 Mar 2024 00:38

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Contributors

Author: David B. N. Lim
Author: Rebecca J. Moon

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