Mortality from thyrotoxicosis in England and Wales and its association with the previous prevalence of endemic goitre
Mortality from thyrotoxicosis in England and Wales and its association with the previous prevalence of endemic goitre
The distribution of mortality from thyrotoxicosis among women in England and Wales during 1968-78 correlates with the previous prevalence of endemic goitre. Mortality from the disease rose to a peak in the decade 1931-40 and then declined. This peak affected all age groups and can be attributed to the high fatality from surgery before the introduction of preoperative iodine to prevent thyroid crisis. An apparent cohort effect, whereby cohorts born from 1871 to 1886 experienced the highest mortality, may be explained by generations with a high prevalence of endemic goitre becoming exposed to increasing dietary iodine intake in later life.
Adult, Age Factors, Aged, England, Female, Goiter, Endemic/epidemiology, Humans, Hyperthyroidism/mortality, Middle Aged, Time Factors, Wales
305-9
Phillips, D I
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Barker, D J
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Winter, P D
3f6d79a4-140a-47e5-b300-310b397b998f
Osmond, C
2677bf85-494f-4a78-adf8-580e1b8acb81
15 December 1983
Phillips, D I
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Barker, D J
0bfdcbdc-bc80-4c0f-9d07-ce3f9f82bc36
Winter, P D
3f6d79a4-140a-47e5-b300-310b397b998f
Osmond, C
2677bf85-494f-4a78-adf8-580e1b8acb81
Phillips, D I, Barker, D J, Winter, P D and Osmond, C
(1983)
Mortality from thyrotoxicosis in England and Wales and its association with the previous prevalence of endemic goitre.
Journal of Epidemiology and Community Health, 37 (4), .
(doi:10.1136/jech.37.4.305).
Abstract
The distribution of mortality from thyrotoxicosis among women in England and Wales during 1968-78 correlates with the previous prevalence of endemic goitre. Mortality from the disease rose to a peak in the decade 1931-40 and then declined. This peak affected all age groups and can be attributed to the high fatality from surgery before the introduction of preoperative iodine to prevent thyroid crisis. An apparent cohort effect, whereby cohorts born from 1871 to 1886 experienced the highest mortality, may be explained by generations with a high prevalence of endemic goitre becoming exposed to increasing dietary iodine intake in later life.
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Published date: 15 December 1983
Keywords:
Adult, Age Factors, Aged, England, Female, Goiter, Endemic/epidemiology, Humans, Hyperthyroidism/mortality, Middle Aged, Time Factors, Wales
Identifiers
Local EPrints ID: 475238
URI: http://eprints.soton.ac.uk/id/eprint/475238
ISSN: 0143-005X
PURE UUID: 0092af06-d55b-4f81-962d-fa128397cd78
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Date deposited: 14 Mar 2023 17:47
Last modified: 17 Mar 2024 02:42
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Author:
D I Phillips
Author:
D J Barker
Author:
P D Winter
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