Current incidence of thyrotoxicosis and past prevalence of goitre in 12 British towns
Current incidence of thyrotoxicosis and past prevalence of goitre in 12 British towns
The incidence of thyrotoxicosis was determined in a collaborative study in 12 towns in England and Wales. Cases were ascertained prospectively through biochemistry laboratories carrying out routine thyroid function tests. The annual incidence varied from 9.7 to 49.2 per 100 000. Reassay of sera at a reference laboratory showed that this variation did not result from inter-laboratory differences in the techniques for measuring thyroid function. The incidence of thyrotoxicosis was strongly correlated with the previous prevalence of endemic goitre in the towns. Current high dietary intakes of iodine--largely the result of milk contamination--may cause toxic nodular goitre in people made susceptible by a lack of iodine early in life. They may also contribute to the occurrence of Graves' disease.
Adolescent, Adult, Aged, Child, England, Female, Goiter/complications, Goiter, Nodular/chemically induced, Humans, Hyperthyroidism/complications, Iodine/adverse effects, Male, Middle Aged, Prospective Studies, Wales
567-70
Barker, D J
0bfdcbdc-bc80-4c0f-9d07-ce3f9f82bc36
Phillips, D I
29b73be7-2ff9-4fff-ae42-d59842df4cc6
8 September 1984
Barker, D J
0bfdcbdc-bc80-4c0f-9d07-ce3f9f82bc36
Phillips, D I
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Barker, D J and Phillips, D I
(1984)
Current incidence of thyrotoxicosis and past prevalence of goitre in 12 British towns.
The Lancet, 2 (8402), .
(doi:10.1016/s0140-6736(84)90776-1).
Abstract
The incidence of thyrotoxicosis was determined in a collaborative study in 12 towns in England and Wales. Cases were ascertained prospectively through biochemistry laboratories carrying out routine thyroid function tests. The annual incidence varied from 9.7 to 49.2 per 100 000. Reassay of sera at a reference laboratory showed that this variation did not result from inter-laboratory differences in the techniques for measuring thyroid function. The incidence of thyrotoxicosis was strongly correlated with the previous prevalence of endemic goitre in the towns. Current high dietary intakes of iodine--largely the result of milk contamination--may cause toxic nodular goitre in people made susceptible by a lack of iodine early in life. They may also contribute to the occurrence of Graves' disease.
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Published date: 8 September 1984
Keywords:
Adolescent, Adult, Aged, Child, England, Female, Goiter/complications, Goiter, Nodular/chemically induced, Humans, Hyperthyroidism/complications, Iodine/adverse effects, Male, Middle Aged, Prospective Studies, Wales
Identifiers
Local EPrints ID: 475239
URI: http://eprints.soton.ac.uk/id/eprint/475239
ISSN: 0140-6736
PURE UUID: fc3ec1c1-0a30-42de-bd8f-eb37f268dced
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Date deposited: 14 Mar 2023 17:47
Last modified: 15 Aug 2024 17:17
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Author:
D J Barker
Author:
D I Phillips
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