The geographical distribution of thyrotoxicosis in England according to the presence or absence of TSH-receptor antibodies
The geographical distribution of thyrotoxicosis in England according to the presence or absence of TSH-receptor antibodies
In a prospective study of the incidence of thyrotoxicosis sera from 216 thyrotoxic patients in seven English towns were assayed for TSH-receptor antibodies. The incidence of antibody negative thyrotoxicosis correlated closely with the previous prevalence of endemic goitre in the towns (r = 0.9) indicating a high current incidence of toxic nodular goitre in previously goitrous towns. Antibody positive thyrotoxicosis, an indicator of Graves' disease, showed no correlation with goitre although there was statistically significant geographical variation in incidence. The percentage of all thyrotoxic patients who were antibody positive varied between towns, from 35% to 92%.
Adolescent, Adult, Age Factors, Aged, Autoantibodies/analysis, Child, England, Goiter, Endemic/epidemiology, Graves Disease/epidemiology, Humans, Hyperthyroidism/epidemiology, Microsomes/immunology, Middle Aged, Prospective Studies, Receptors, Cell Surface/immunology, Receptors, Thyrotropin
283-7
Phillips, D I
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Barker, D J
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Rees Smith, B
c7b04994-3388-4689-838f-710a3a781433
Didcote, S
dd74bb99-12d1-4423-9372-0d028dc338f2
Morgan, D
4201f9bb-84c5-4a3d-873c-170756196b5f
15 September 1985
Phillips, D I
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Barker, D J
0bfdcbdc-bc80-4c0f-9d07-ce3f9f82bc36
Rees Smith, B
c7b04994-3388-4689-838f-710a3a781433
Didcote, S
dd74bb99-12d1-4423-9372-0d028dc338f2
Morgan, D
4201f9bb-84c5-4a3d-873c-170756196b5f
Phillips, D I, Barker, D J, Rees Smith, B, Didcote, S and Morgan, D
(1985)
The geographical distribution of thyrotoxicosis in England according to the presence or absence of TSH-receptor antibodies.
Clinical Endocrinology, 23 (3), .
(doi:10.1111/j.1365-2265.1985.tb00225.x).
Abstract
In a prospective study of the incidence of thyrotoxicosis sera from 216 thyrotoxic patients in seven English towns were assayed for TSH-receptor antibodies. The incidence of antibody negative thyrotoxicosis correlated closely with the previous prevalence of endemic goitre in the towns (r = 0.9) indicating a high current incidence of toxic nodular goitre in previously goitrous towns. Antibody positive thyrotoxicosis, an indicator of Graves' disease, showed no correlation with goitre although there was statistically significant geographical variation in incidence. The percentage of all thyrotoxic patients who were antibody positive varied between towns, from 35% to 92%.
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Published date: 15 September 1985
Keywords:
Adolescent, Adult, Age Factors, Aged, Autoantibodies/analysis, Child, England, Goiter, Endemic/epidemiology, Graves Disease/epidemiology, Humans, Hyperthyroidism/epidemiology, Microsomes/immunology, Middle Aged, Prospective Studies, Receptors, Cell Surface/immunology, Receptors, Thyrotropin
Identifiers
Local EPrints ID: 475241
URI: http://eprints.soton.ac.uk/id/eprint/475241
ISSN: 0300-0664
PURE UUID: 71ba1c85-7646-432a-8b19-ede9a4e80711
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Date deposited: 14 Mar 2023 17:47
Last modified: 17 Mar 2024 00:52
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Author:
D I Phillips
Author:
D J Barker
Author:
B Rees Smith
Author:
S Didcote
Author:
D Morgan
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