A relationship between impaired fetal growth and reduced muscle glycolysis revealed by 31P magnetic resonance spectroscopy
A relationship between impaired fetal growth and reduced muscle glycolysis revealed by 31P magnetic resonance spectroscopy
Thinness at birth is associated with insulin resistance and an increased prevalence of non-insulin-dependent diabetes mellitus in adult life. As muscle is an important site of insulin resistance, and because thin babies have reduced muscle mass, thinness at birth may affect muscle structure and function and impair carbohydrate metabolism. We have therefore used 31P magnetic resonance spectroscopy to investigate the bioenergetics of gastrocnemius and flexor digitorum superficialis muscles in 16 normoglycaemic women who had a low ( < or = 23 kg/m3) and 9 women who had a high (> 23 kg/m3) ponderal index at birth. In the flexor digitorum superficialis study anaerobic metabolism was stressed with a constant heavy workload. Low ponderal index subjects fatigued more rapidly (3.3 vs 5.8 min); as phosphocreatine decreased, the accompanying drop in muscle pH was less than in the high ponderal index group. In the first minute of exercise phosphocreatine fell and adenosine diphosphate rose more rapidly (p=0.04 and 0.03, respectively). Gastrocnemius showed a similar trend late in exercise (this exercise was more oxidative, becoming more anaerobic with increasing workload). These changes were not explained by differences in body composition, muscle mass or blood flow. The findings are consistent with a decreased lactic acid and glycolytic adenosine triphosphate production in the low ponderal index group and suggest the possibility that the mechanisms which control substrate utilisation and metabolism in adult life be programmed during prenatal life.
Adenosine Diphosphate/metabolism, Adenosine Triphosphate/metabolism, Birth Weight, Capillaries/physiology, Embryonic and Fetal Development, Energy Metabolism, Female, Glycolysis, Humans, Infant, Newborn, Magnetic Resonance Spectroscopy, Muscle Fibers, Skeletal/metabolism, Muscle, Skeletal/blood supply, Organ Specificity, Phosphates/metabolism, Phosphocreatine/metabolism, Phosphorus, Physical Exertion, Pregnancy/metabolism, Reference Values, Spectrophotometry, Infrared
1205-1212
Taylor, D J
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Thompson, C H
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Kemp, G J
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Barnes, P R
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Sanderson, A L
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Radda, G K
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Phillips, D I
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15 October 1995
Taylor, D J
67eccc76-8b42-44cd-9000-0f8950593adf
Thompson, C H
be15476e-f7ba-4b4b-9598-a600273689a5
Kemp, G J
cd2a692e-222f-4c34-86fd-ceacbdb59215
Barnes, P R
4bd2e0ea-93e4-4f8b-ac89-cd43b2555dc2
Sanderson, A L
4b3e892d-e671-4dd6-bf3a-90e5fa701c81
Radda, G K
3a67afe9-5dd9-46b8-a2d6-9b9c0e7049b1
Phillips, D I
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Taylor, D J, Thompson, C H, Kemp, G J, Barnes, P R, Sanderson, A L, Radda, G K and Phillips, D I
(1995)
A relationship between impaired fetal growth and reduced muscle glycolysis revealed by 31P magnetic resonance spectroscopy.
Diabetologia, 38 (10), .
(doi:10.1007/BF00422370).
Abstract
Thinness at birth is associated with insulin resistance and an increased prevalence of non-insulin-dependent diabetes mellitus in adult life. As muscle is an important site of insulin resistance, and because thin babies have reduced muscle mass, thinness at birth may affect muscle structure and function and impair carbohydrate metabolism. We have therefore used 31P magnetic resonance spectroscopy to investigate the bioenergetics of gastrocnemius and flexor digitorum superficialis muscles in 16 normoglycaemic women who had a low ( < or = 23 kg/m3) and 9 women who had a high (> 23 kg/m3) ponderal index at birth. In the flexor digitorum superficialis study anaerobic metabolism was stressed with a constant heavy workload. Low ponderal index subjects fatigued more rapidly (3.3 vs 5.8 min); as phosphocreatine decreased, the accompanying drop in muscle pH was less than in the high ponderal index group. In the first minute of exercise phosphocreatine fell and adenosine diphosphate rose more rapidly (p=0.04 and 0.03, respectively). Gastrocnemius showed a similar trend late in exercise (this exercise was more oxidative, becoming more anaerobic with increasing workload). These changes were not explained by differences in body composition, muscle mass or blood flow. The findings are consistent with a decreased lactic acid and glycolytic adenosine triphosphate production in the low ponderal index group and suggest the possibility that the mechanisms which control substrate utilisation and metabolism in adult life be programmed during prenatal life.
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Published date: 15 October 1995
Keywords:
Adenosine Diphosphate/metabolism, Adenosine Triphosphate/metabolism, Birth Weight, Capillaries/physiology, Embryonic and Fetal Development, Energy Metabolism, Female, Glycolysis, Humans, Infant, Newborn, Magnetic Resonance Spectroscopy, Muscle Fibers, Skeletal/metabolism, Muscle, Skeletal/blood supply, Organ Specificity, Phosphates/metabolism, Phosphocreatine/metabolism, Phosphorus, Physical Exertion, Pregnancy/metabolism, Reference Values, Spectrophotometry, Infrared
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Local EPrints ID: 475269
URI: http://eprints.soton.ac.uk/id/eprint/475269
ISSN: 0012-186X
PURE UUID: 95d12e49-36d4-4176-817f-bdc7fba78b2b
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Date deposited: 14 Mar 2023 17:59
Last modified: 17 Mar 2024 00:52
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Author:
D J Taylor
Author:
C H Thompson
Author:
G J Kemp
Author:
P R Barnes
Author:
A L Sanderson
Author:
G K Radda
Author:
D I Phillips
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