Weight gain in infancy and cancer of the ovary
Weight gain in infancy and cancer of the ovary
The geographic association between ovarian cancer and tall stature suggests a link with rapid growth in early childhood. Among 5585 women born in Hertfordshire, UK, 41 who died from ovarian cancer had had a high rate of weight gain in infancy. Whereas their mean birthweight was the same as that of the other women, their mean weight at 1 year was higher (22.3 pounds [10.1 kg] vs 21.4 pounds [9.7 kg], p = 0.01). These observations are consistent with the hypothesis that ovarian cancer is linked to altered patterns of gonadotropin release established in utero when the fetal hypothalamus is imprinted.
Adult, Aged, Diet, Female, Gonadotropins/metabolism, Humans, Infant, Middle Aged, Ovarian Neoplasms/mortality, Risk Factors, Weight Gain
1087-8
Barker, D J
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Winter, P D
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Osmond, C
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Phillips, D I
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Sultan, H Y
ed54b15f-86ca-4ce0-8305-2f0836a0e86f
29 April 1995
Barker, D J
0bfdcbdc-bc80-4c0f-9d07-ce3f9f82bc36
Winter, P D
50dd83cd-0c8c-4d19-8c03-95537ee554bb
Osmond, C
2677bf85-494f-4a78-adf8-580e1b8acb81
Phillips, D I
29b73be7-2ff9-4fff-ae42-d59842df4cc6
Sultan, H Y
ed54b15f-86ca-4ce0-8305-2f0836a0e86f
Barker, D J, Winter, P D, Osmond, C, Phillips, D I and Sultan, H Y
(1995)
Weight gain in infancy and cancer of the ovary.
The Lancet, 345 (8957), .
(doi:10.1016/s0140-6736(95)90821-8).
Abstract
The geographic association between ovarian cancer and tall stature suggests a link with rapid growth in early childhood. Among 5585 women born in Hertfordshire, UK, 41 who died from ovarian cancer had had a high rate of weight gain in infancy. Whereas their mean birthweight was the same as that of the other women, their mean weight at 1 year was higher (22.3 pounds [10.1 kg] vs 21.4 pounds [9.7 kg], p = 0.01). These observations are consistent with the hypothesis that ovarian cancer is linked to altered patterns of gonadotropin release established in utero when the fetal hypothalamus is imprinted.
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Published date: 29 April 1995
Keywords:
Adult, Aged, Diet, Female, Gonadotropins/metabolism, Humans, Infant, Middle Aged, Ovarian Neoplasms/mortality, Risk Factors, Weight Gain
Identifiers
Local EPrints ID: 475270
URI: http://eprints.soton.ac.uk/id/eprint/475270
ISSN: 0140-6736
PURE UUID: 65cafc2d-4506-4d66-a292-53a0bbcde73f
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Date deposited: 14 Mar 2023 17:59
Last modified: 17 Mar 2024 02:42
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Author:
D J Barker
Author:
P D Winter
Author:
D I Phillips
Author:
H Y Sultan
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