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Getting stress out of stressed-out stress granules

Getting stress out of stressed-out stress granules
Getting stress out of stressed-out stress granules

Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal, Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase transition of these stress granules from liquid to solid. This discovery provides a model connecting protein aggregation to stress granule dysfunction.

Cytoplasmic Granules, Humans, RNA, Messenger, Stress, Physiological
0261-4189
1647-1649
Siwach, Pratibha
843aa2e1-7d29-4ddd-935b-a3dca67c7a90
Kaganovich, Daniel
ebb13f4e-e925-4aef-88e7-ddc25ef52d8f
Siwach, Pratibha
843aa2e1-7d29-4ddd-935b-a3dca67c7a90
Kaganovich, Daniel
ebb13f4e-e925-4aef-88e7-ddc25ef52d8f

Siwach, Pratibha and Kaganovich, Daniel (2017) Getting stress out of stressed-out stress granules. The EMBO Journal, 36 (12), 1647-1649. (doi:10.15252/embj.201797176).

Record type: Article

Abstract

Amyotrophic lateral sclerosis (ALS) pathology is linked to the aberrant aggregation of specific proteins, including TDP‐43, FUS, and SOD1, but it is not clear why these aggregation events cause ALS. In this issue of The EMBO Journal, Mateju et al (2017) report a direct link between misfolded proteins accumulating in stress granules and the phase transition of these stress granules from liquid to solid. This discovery provides a model connecting protein aggregation to stress granule dysfunction.

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More information

Published date: 14 June 2017
Keywords: Cytoplasmic Granules, Humans, RNA, Messenger, Stress, Physiological

Identifiers

Local EPrints ID: 475570
URI: http://eprints.soton.ac.uk/id/eprint/475570
DOI: doi:10.15252/embj.201797176
ISSN: 0261-4189
PURE UUID: 4d36b723-183a-40bb-adfd-20e0ec7fe79a
ORCID for Daniel Kaganovich: ORCID iD orcid.org/0000-0003-2398-1596

Catalogue record

Date deposited: 21 Mar 2023 17:49
Last modified: 17 Mar 2024 04:17

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Contributors

Author: Pratibha Siwach
Author: Daniel Kaganovich ORCID iD

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