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Look out autophagy, Ubiquilin ups its game

Look out autophagy, Ubiquilin ups its game
Look out autophagy, Ubiquilin ups its game
Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has remained unknown. Hjerpe et. al now report that Ubiquilin-2 enables the ubiquitin proteasome system (UPS) to single-handedly clear aggregated proteins, a cellular function previously thought to rely at least partially on autophagy.
Amyotrophic Lateral Sclerosis/genetics, Autophagy, Cell Cycle Proteins/genetics, Humans, Proteasome Endopeptidase Complex/metabolism, Ubiquitin/metabolism, Ubiquitins/genetics
0092-8674
797-799
Brown, Rachel
6a00909e-6ed5-4b82-8532-71909045784b
Kaganovich, Daniel
ebb13f4e-e925-4aef-88e7-ddc25ef52d8f
Brown, Rachel
6a00909e-6ed5-4b82-8532-71909045784b
Kaganovich, Daniel
ebb13f4e-e925-4aef-88e7-ddc25ef52d8f

Brown, Rachel and Kaganovich, Daniel (2016) Look out autophagy, Ubiquilin ups its game. Cell, 166 (4), 797-799. (doi:10.1016/j.cell.2016.07.048).

Record type: Article

Abstract

Mutations in Ubiquilin-2 are linked to the onset of amyotrophic lateral sclerosis, but its connection to disease processes has remained unknown. Hjerpe et. al now report that Ubiquilin-2 enables the ubiquitin proteasome system (UPS) to single-handedly clear aggregated proteins, a cellular function previously thought to rely at least partially on autophagy.

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More information

Published date: 11 August 2016
Additional Information: Copyright © 2016 Elsevier Inc. All rights reserved.
Keywords: Amyotrophic Lateral Sclerosis/genetics, Autophagy, Cell Cycle Proteins/genetics, Humans, Proteasome Endopeptidase Complex/metabolism, Ubiquitin/metabolism, Ubiquitins/genetics

Identifiers

Local EPrints ID: 475602
URI: http://eprints.soton.ac.uk/id/eprint/475602
DOI: doi:10.1016/j.cell.2016.07.048
ISSN: 0092-8674
PURE UUID: 85cb8dad-7ed9-4ba3-844d-19fd00d18310
ORCID for Daniel Kaganovich: ORCID iD orcid.org/0000-0003-2398-1596

Catalogue record

Date deposited: 22 Mar 2023 17:36
Last modified: 17 Mar 2024 04:17

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Contributors

Author: Rachel Brown
Author: Daniel Kaganovich ORCID iD

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