Effectiveness of rapid SARS-CoV-2 genome sequencing in supporting infection control for hospital-onset COVID-19 infection: multicenter, prospective study

Accepted/In Press date: 25 August 2022

Published date: 13 September 2022

Additional Information: Funding Information: COG‐UK is supported by funding from the Medical Research Council (MRC) part of UK Research & Innovation (UKRI), the National Institute of Health Research (NIHR) [grant code: MC_PC_19027], and Genome Research Limited, operating as the Wellcome Sanger Institute. COG‐UK is supported by funding from the Medical Research Council (MRC) part of UK Research & Innovation (UKRI), the National Institute of Health Research (NIHR) [grant code: MC_PC_19027], and Genome Research Limited, operating as the Wellcome Sanger Institute. UCLH APDU is funded by the UCLH NHS Foundation Trust and the UCLH NIHR BRC. MRC‐University of Glasgow Centre for Virus Research has received funding from the Medical Research Council. SR is part‐funded from Research England’s Expanding Excellence in England (E3) Fund, and additional funding for sequencing of SARS‐CoV‐2 at University of Portsmouth came from the Wessex Academic Health Sciences Centre (AHSC). FC was funded by a Wellcome Trust Sir Henry Postdoctoral Fellowship. LS has received support for research from NIHR Biomedical Research Centre at Guy’s and St Thomas NHS Foundation Trust, Guy’s & St Thomas Charity and King’s Health Partners. We also acknowledge the support of the independent members of the Joint Trial Steering Committee and Data Monitoring Committee (TSC‐DMC): Prof Marion Koopmans (Erasmus MC), Prof Walter Zingg (University of Geneva), Prof Colm Bergin (Trinity College Dublin), Prof Karla Hemming (University of Birmingham), Prof Katherine Fielding (LSHTM). As well as TSC‐DMC non‐independent members: Prof Nick Lemoine (NIHR CRN), Prof Sharon Peacock (COG‐UK). We would also thank members of COG‐UK who have directly supported the study: Dr Ewan Harrison (Cambridge University), Dr Katerina Galai (PHE), Dr Francesc Coll (LSHTM), Dr Michael Chapman (HDR‐UK), Prof Thomas Connor and team (Cardiff University), Prof Nick Loman and team (University of Birmingham). We also thank the COG‐UK Consortium, and the UK National Institute for Health Research Clinical Research Network (NIHR CRN). Funding Information:  COG 爀栀K is supported by funding from the Medical Research Couln c縀i MRC 缀 part of ?K Research 頀  Innovation 縀?KRI 缃? the National Institute of Health ReseaIrHchR ? ? 老N倁? ant code P MC YPC Y ? ? 脃? and  Genome Research Limited 唀 operatgin as the Wellcome Sanger Institute 堀 Funding Information: C L H APD? is funded by the ?CLH NHS Foundation Trust and the ?CLH NIHR BRC ? MRC ? ?niversity of G lasgow Centre for Virus Research has received funding from the Medical Research Council 堀 SR is p art ?funded from Research England ?s Expanding Excellence inl aEndg ?E ? 缀 Fund 唀 and additional f unding for sequencing of SARS 爀CoV 爃 at ?niversity of Portshm coaumt e from the Wessex Academic H ealth Sciences Centre ?AHSC ?C ?wa Fs funded by a Wellcome Trust Sir Henry Postdoctoral F ellowship ? LS has received suppto fror research from NIHR Biomedical Research Centre at Guy 嬁退 and S t Thomas NHS Foundation Trust 唀Gu y ? s ? St Thomas Charity anindg K 嬁退 Health Partners 堀 Publisher Copyright: © 2022, eLife Sciences Publications Ltd. All rights reserved. This article contains valuable information on the potential value of real-time genome sequencing to inform infection control practices. The study, unique in its size, addresses the implementation of this approach during the height of the COVID-19 pandemic. Naturally, the extreme situation limited the options for choices in infection control practices.

Keywords: COVID-19, epidemiology, global health, healthcare-associated infection, hospital-acquired infection, human, infection control, infection prevention, infectious disease, microbiology, molecular epidemiology, viral genomics

Local EPrints ID: 475639

URI: http://eprints.soton.ac.uk/id/eprint/475639

DOI: doi:10.7554/eLife.78427

ISSN: 2050-084X

PURE UUID: 4ffcea09-5286-48ff-92a0-ff086d0ef066

ORCID for Kordo Saeed: orcid.org/0000-0003-0123-0302

Date deposited: 23 Mar 2023 17:35

Last modified: 06 Jun 2024 02:06