Predictors of prolonged symptoms following COVID-19 and other respiratory infections
Predictors of prolonged symptoms following COVID-19 and other respiratory infections
Background: post-viral syndromes following respiratory tract infections have been described for years. Early studies of COVID-19 have suggested that around 2% of people who develop acute infection will still have symptoms at 12 weeks. Understanding predictors of prolonged symptoms may help inform early management and healthcare planning.
Aim: to explore predictors of prolonged symptoms in a community cohort reporting acute respiratory tract infection during the first year of the COVID-19 pandemic.Methods:We conducted an online survey of adults through advertising to the public and invitations sent by general practices. Participants were asked to report details of any respiratory infections lasting 3 days or more and asked to report any prolonged symptoms in a follow-up survey sent 3-months later. Clustering of prolonged symptoms was explored using factor analysis. Demographics, past medical history, and features of the acute illness were all considered as potential predictors. We used LASSO to select predictors and then logistic regression to estimate the association with experiencing prolonged symptoms.
Results: 1,942 participants reported an ARI in the baseline questionnaire and completed a 3-month follow-upquestionnaire. Of these, 464 (23.9%) reported having prolonged symptoms. The most common prolonged symptoms were tiredness, ‘brain fog’ and shortness of breath. Preliminary analysis has identified having laboratory confirmed or ‘probable’ COVID, older age, female sex, greater socioeconomic deprivation, greater concern about the initial illness, and shortness of breath, loss of taste and skin rash, as predictors of prolonged symptoms.
Discussion: the analysis is ongoing and will be presented at the meeting.
Francis, N.A.
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Willcox, Merlin
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Becque, Taeko
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Little, Paul
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Alwan, Nisreen
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Hay, Alastair
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Stuart, Beth
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Moore, Michael
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23 September 2022
Francis, N.A.
9b610883-605c-4fee-871d-defaa86ccf8e
Willcox, Merlin
dad5b622-9ac2-417d-9b2e-aad41b64ffea
Becque, Taeko
ecd1b4d5-4db8-4442-81c2-04aa291cf2fd
Little, Paul
1bf2d1f7-200c-47a5-ab16-fe5a8756a777
Alwan, Nisreen
0d37b320-f325-4ed3-ba51-0fe2866d5382
Hay, Alastair
daf3c71f-5e5a-4bee-9bb8-7df67ec2a79f
Stuart, Beth
626862fc-892b-4f6d-9cbb-7a8d7172b209
Moore, Michael
1be81dad-7120-45f0-bbed-f3b0cc0cfe99
Francis, N.A., Willcox, Merlin, Becque, Taeko, Little, Paul, Alwan, Nisreen, Hay, Alastair, Stuart, Beth and Moore, Michael
(2022)
Predictors of prolonged symptoms following COVID-19 and other respiratory infections.
General Practice Resarch on Infections Network, University of Lund, Lund, Sweden.
23 - 24 Sep 2022.
Record type:
Conference or Workshop Item
(Paper)
Abstract
Background: post-viral syndromes following respiratory tract infections have been described for years. Early studies of COVID-19 have suggested that around 2% of people who develop acute infection will still have symptoms at 12 weeks. Understanding predictors of prolonged symptoms may help inform early management and healthcare planning.
Aim: to explore predictors of prolonged symptoms in a community cohort reporting acute respiratory tract infection during the first year of the COVID-19 pandemic.Methods:We conducted an online survey of adults through advertising to the public and invitations sent by general practices. Participants were asked to report details of any respiratory infections lasting 3 days or more and asked to report any prolonged symptoms in a follow-up survey sent 3-months later. Clustering of prolonged symptoms was explored using factor analysis. Demographics, past medical history, and features of the acute illness were all considered as potential predictors. We used LASSO to select predictors and then logistic regression to estimate the association with experiencing prolonged symptoms.
Results: 1,942 participants reported an ARI in the baseline questionnaire and completed a 3-month follow-upquestionnaire. Of these, 464 (23.9%) reported having prolonged symptoms. The most common prolonged symptoms were tiredness, ‘brain fog’ and shortness of breath. Preliminary analysis has identified having laboratory confirmed or ‘probable’ COVID, older age, female sex, greater socioeconomic deprivation, greater concern about the initial illness, and shortness of breath, loss of taste and skin rash, as predictors of prolonged symptoms.
Discussion: the analysis is ongoing and will be presented at the meeting.
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Published date: 23 September 2022
Venue - Dates:
General Practice Resarch on Infections Network, University of Lund, Lund, Sweden, 2022-09-23 - 2022-09-24
Identifiers
Local EPrints ID: 475732
URI: http://eprints.soton.ac.uk/id/eprint/475732
PURE UUID: 90823119-9bb7-4f39-96a7-8916be24d429
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Date deposited: 27 Mar 2023 16:39
Last modified: 11 Jul 2024 02:05
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Contributors
Author:
Alastair Hay
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