Anthraquinone-oligodeoxynucleotide conjugates as triple helix stabilizing agents
Anthraquinone-oligodeoxynucleotide conjugates as triple helix stabilizing agents
A number of anthraquinones have been synthesized and linked to a 10-mer homopyrimidine oligodeoxynucleotide. All the anthraquinone-oligodeoxynucleotide conjugates exhibited sequence specific triple helix formation when tested by DNase I footprinting. Neither the presence of an ionizable side chain nor the position of substitution of the anthraquinone appeared to affect triplex stability.
49-53
Gibson, V.
16c18550-a1e1-4ee2-961e-3e7927c577d3
Anderson, R. J.
91c527c6-04f5-41ba-9e77-2d640cfe2cab
Brown, J. R.
9445df76-d13c-4679-960f-308610ba301d
Hartley, J. A.
f8056065-0539-45c4-b1b3-1aa4b6f6ccac
Cassidy, S. A.
085eb22e-9576-4ed7-8e22-89028b6086ba
Fox, K. R.
9da5debc-4e45-473e-ab8c-550d1104659f
Cairns, D.
bd438a6e-75b2-43b7-9d53-33246e7e71f8
1996
Gibson, V.
16c18550-a1e1-4ee2-961e-3e7927c577d3
Anderson, R. J.
91c527c6-04f5-41ba-9e77-2d640cfe2cab
Brown, J. R.
9445df76-d13c-4679-960f-308610ba301d
Hartley, J. A.
f8056065-0539-45c4-b1b3-1aa4b6f6ccac
Cassidy, S. A.
085eb22e-9576-4ed7-8e22-89028b6086ba
Fox, K. R.
9da5debc-4e45-473e-ab8c-550d1104659f
Cairns, D.
bd438a6e-75b2-43b7-9d53-33246e7e71f8
Gibson, V., Anderson, R. J., Brown, J. R., Hartley, J. A., Cassidy, S. A., Fox, K. R. and Cairns, D.
(1996)
Anthraquinone-oligodeoxynucleotide conjugates as triple helix stabilizing agents.
Pharmaceutical Sciences, 2 (1), .
Abstract
A number of anthraquinones have been synthesized and linked to a 10-mer homopyrimidine oligodeoxynucleotide. All the anthraquinone-oligodeoxynucleotide conjugates exhibited sequence specific triple helix formation when tested by DNase I footprinting. Neither the presence of an ionizable side chain nor the position of substitution of the anthraquinone appeared to affect triplex stability.
This record has no associated files available for download.
More information
Published date: 1996
Identifiers
Local EPrints ID: 475866
URI: http://eprints.soton.ac.uk/id/eprint/475866
ISSN: 1356-6881
PURE UUID: 64c864ed-441f-4cfa-8d98-c3b1dd6fd3d5
Catalogue record
Date deposited: 29 Mar 2023 16:46
Last modified: 30 Mar 2023 01:32
Export record
Contributors
Author:
V. Gibson
Author:
R. J. Anderson
Author:
J. R. Brown
Author:
J. A. Hartley
Author:
S. A. Cassidy
Author:
D. Cairns
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
