The University of Southampton
University of Southampton Institutional Repository

Association between autism spectrum disorder and diabetes: systematic review and meta-analysis

Association between autism spectrum disorder and diabetes: systematic review and meta-analysis
Association between autism spectrum disorder and diabetes: systematic review and meta-analysis

There is mixed evidence on the link between autism spectrum disorder (ASD) and diabetes. We conducted the first systematic review/meta-analysis on their association. Based on a pre-registered protocol (PROSPERO: CRD42021261114), we searched Pubmed, Ovid, and Web of Science databases up to 6 December 2021, with no language/type of document restrictions. We assessed study quality using the Newcastle-Ottawa Scale (NOS). We included 24 studies (total: 3427,773 individuals; 237,529 with ASD and 92,832 with diabetes) in the systematic review and 20 in the meta-analysis (mean stars number on the NOS: 5.89/10). There was a significant association, albeit characterized by significant heterogeneity, when pooling unadjusted OR (1.535, 95% CI = 1.109-2.126), which remained significant when restricting the analysis to children and type 2 diabetes, but became non-significant when considering adjusted ORs (OR: 1.528, 95% CI = 0.954-2.448). No significant prospective association was found (n = 2) on diabetes predicting ASD (HR: 1.232, 0.826-11.837). Therefore, the association between ASD and diabetes is likely confounded by demographic and clinical factors that should be systematically investigated in future studies.

Autism Spectrum Disorder/complications, Child, Diabetes Mellitus, Type 2/complications, Humans
0149-7634
104592
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Gabellone, Alessandra
f1b8d033-0070-49aa-9e0a-3e5e36d17aaf
Marzulli, Lucia
3f554484-1473-4d8b-b01c-1b01ba64c834
Iturmendi-Sabater, Iciar
fc0683c9-f0e8-4ae1-800c-41f9456a2e37
de La Chica-Duarte, Diego
d32e3c35-e31d-44d0-9d45-3aadea628d4b
Piqué, Isabella M.
26add54b-859a-4644-b84a-8d3d000095f5
Solmi, Marco
256504f2-483a-4b42-bfab-081c6a617867
Shin, Jae Il
cc12b7c4-5ec5-4903-a6de-9d1cb61dabde
Margari, Lucia
cd19d7f3-f363-433b-a255-f65121b4d543
Arrondo, Gonzalo
5b9c1446-74f9-4dc7-aa73-6c67f3eaddbc
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Gabellone, Alessandra
f1b8d033-0070-49aa-9e0a-3e5e36d17aaf
Marzulli, Lucia
3f554484-1473-4d8b-b01c-1b01ba64c834
Iturmendi-Sabater, Iciar
fc0683c9-f0e8-4ae1-800c-41f9456a2e37
de La Chica-Duarte, Diego
d32e3c35-e31d-44d0-9d45-3aadea628d4b
Piqué, Isabella M.
26add54b-859a-4644-b84a-8d3d000095f5
Solmi, Marco
256504f2-483a-4b42-bfab-081c6a617867
Shin, Jae Il
cc12b7c4-5ec5-4903-a6de-9d1cb61dabde
Margari, Lucia
cd19d7f3-f363-433b-a255-f65121b4d543
Arrondo, Gonzalo
5b9c1446-74f9-4dc7-aa73-6c67f3eaddbc

Cortese, Samuele, Gabellone, Alessandra, Marzulli, Lucia, Iturmendi-Sabater, Iciar, de La Chica-Duarte, Diego, Piqué, Isabella M., Solmi, Marco, Shin, Jae Il, Margari, Lucia and Arrondo, Gonzalo (2022) Association between autism spectrum disorder and diabetes: systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 136, 104592. (doi:10.1016/j.neubiorev.2022.104592).

Record type: Review

Abstract

There is mixed evidence on the link between autism spectrum disorder (ASD) and diabetes. We conducted the first systematic review/meta-analysis on their association. Based on a pre-registered protocol (PROSPERO: CRD42021261114), we searched Pubmed, Ovid, and Web of Science databases up to 6 December 2021, with no language/type of document restrictions. We assessed study quality using the Newcastle-Ottawa Scale (NOS). We included 24 studies (total: 3427,773 individuals; 237,529 with ASD and 92,832 with diabetes) in the systematic review and 20 in the meta-analysis (mean stars number on the NOS: 5.89/10). There was a significant association, albeit characterized by significant heterogeneity, when pooling unadjusted OR (1.535, 95% CI = 1.109-2.126), which remained significant when restricting the analysis to children and type 2 diabetes, but became non-significant when considering adjusted ORs (OR: 1.528, 95% CI = 0.954-2.448). No significant prospective association was found (n = 2) on diabetes predicting ASD (HR: 1.232, 0.826-11.837). Therefore, the association between ASD and diabetes is likely confounded by demographic and clinical factors that should be systematically investigated in future studies.

Text
1-s2.0-S0149763422000811-main - Version of Record
Download (1MB)

More information

Accepted/In Press date: 20 February 2022
e-pub ahead of print date: 22 February 2022
Published date: 29 April 2022
Additional Information: Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Keywords: Autism Spectrum Disorder/complications, Child, Diabetes Mellitus, Type 2/complications, Humans

Identifiers

Local EPrints ID: 476093
URI: http://eprints.soton.ac.uk/id/eprint/476093
ISSN: 0149-7634
PURE UUID: 0496cd86-0182-4c3e-880c-001899bf6883
ORCID for Samuele Cortese: ORCID iD orcid.org/0000-0001-5877-8075

Catalogue record

Date deposited: 12 Apr 2023 11:54
Last modified: 17 Mar 2024 03:37

Export record

Altmetrics

Contributors

Author: Samuele Cortese ORCID iD
Author: Alessandra Gabellone
Author: Lucia Marzulli
Author: Iciar Iturmendi-Sabater
Author: Diego de La Chica-Duarte
Author: Isabella M. Piqué
Author: Marco Solmi
Author: Jae Il Shin
Author: Lucia Margari
Author: Gonzalo Arrondo

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×