A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity
A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity
From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus-pituitary-adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA-related clinical states.
hypothalamus-pituitary-adrenal axis, hpa, stress, glucocorticoids, genes, heritability, twins
52-62
Wüst, S.
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Federenko, I.S.
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van Rossum, E.F.
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Koper, J.W.
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Kumsta, R.
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Entringer, S.
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Hellhammer, D.H.
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December 2004
Wüst, S.
96e48b7c-9aa0-4279-83d9-86b63e1d6303
Federenko, I.S.
f56fed39-6107-487a-922f-41ce6fb12a63
van Rossum, E.F.
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Koper, J.W.
b35e9497-5af3-41ad-b0e3-ff7210f86d08
Kumsta, R.
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Entringer, S.
7a3581e3-5d89-406b-8631-7bdd3aa78eb8
Hellhammer, D.H.
2e2b65d7-69f2-40bc-84be-ba10e093c016
Wüst, S., Federenko, I.S., van Rossum, E.F., Koper, J.W., Kumsta, R., Entringer, S. and Hellhammer, D.H.
(2004)
A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity.
Annals of the New York Academy of Sciences, 1032 (1), .
(doi:10.1196/annals.1314.005).
Abstract
From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus-pituitary-adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA-related clinical states.
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Published date: December 2004
Keywords:
hypothalamus-pituitary-adrenal axis, hpa, stress, glucocorticoids, genes, heritability, twins
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Local EPrints ID: 47617
URI: http://eprints.soton.ac.uk/id/eprint/47617
ISSN: 0077-8923
PURE UUID: 9fe4e989-b9ce-4281-b516-2f44429f52fa
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Date deposited: 06 Aug 2007
Last modified: 15 Mar 2024 09:34
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Author:
S. Wüst
Author:
I.S. Federenko
Author:
E.F. van Rossum
Author:
J.W. Koper
Author:
R. Kumsta
Author:
S. Entringer
Author:
D.H. Hellhammer
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