Reducing suspicion of sexual abuse in paediatric chlamydial conjunctivitis using ompA genotyping.
Reducing suspicion of sexual abuse in paediatric chlamydial conjunctivitis using ompA genotyping.
Chlamydia trachomatis is a Gram-negative bacterium that causes urogenital tract infections, and ocular infections including trachoma, neonatal conjunctivitis and adult chlamydial inclusion conjunctivitis. A positive C. trachomatis diagnosis in children often raises suspicions of sexual abuse. While outer membrane protein A (ompA) genotypes A–C are non-invasive and are associated with trachoma; ompA genotypes D–K are often associated with sexually transmitted urogenital infections or sexually acquired chlamydial conjunctivitis. A 10-year-old female presented with a 7-month history of unilateral conjunctivitis with itching, watering and hyperaemia. She had recently moved from an urban centre in Afghanistan to the UK. A conjunctival swab taken from the child tested positive for C. trachomatis. Application of ompA genotyping to conjunctival swab chlamydial DNA demonstrated that the C. trachomatis had an ompA genotype C. Chlamydial strains with this ompA genotype cause trachoma and have never previously been associated with urogenital infection. This result supported cessation of child protection investigations.
e238871
Mitchell, Alexander
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Patel, Mitul
687cfdcc-16c1-41bb-98c2-74bd66a7c8ac
Manning, Chloe
9a17a65f-aec6-4dde-9b72-8ee21845564f
Abbott, Joseph
a732773e-0587-44c4-9ce3-e3bc166d7131
Mitchell, Alexander
b295f173-f694-468b-a580-22e57978601a
Patel, Mitul
687cfdcc-16c1-41bb-98c2-74bd66a7c8ac
Manning, Chloe
9a17a65f-aec6-4dde-9b72-8ee21845564f
Abbott, Joseph
a732773e-0587-44c4-9ce3-e3bc166d7131
Mitchell, Alexander, Patel, Mitul, Manning, Chloe and Abbott, Joseph
(2021)
Reducing suspicion of sexual abuse in paediatric chlamydial conjunctivitis using ompA genotyping.
BMJ Case Reports, 14 (3), .
(doi:10.1136/bcr-2020-238871).
Abstract
Chlamydia trachomatis is a Gram-negative bacterium that causes urogenital tract infections, and ocular infections including trachoma, neonatal conjunctivitis and adult chlamydial inclusion conjunctivitis. A positive C. trachomatis diagnosis in children often raises suspicions of sexual abuse. While outer membrane protein A (ompA) genotypes A–C are non-invasive and are associated with trachoma; ompA genotypes D–K are often associated with sexually transmitted urogenital infections or sexually acquired chlamydial conjunctivitis. A 10-year-old female presented with a 7-month history of unilateral conjunctivitis with itching, watering and hyperaemia. She had recently moved from an urban centre in Afghanistan to the UK. A conjunctival swab taken from the child tested positive for C. trachomatis. Application of ompA genotyping to conjunctival swab chlamydial DNA demonstrated that the C. trachomatis had an ompA genotype C. Chlamydial strains with this ompA genotype cause trachoma and have never previously been associated with urogenital infection. This result supported cessation of child protection investigations.
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Accepted/In Press date: 19 March 2021
e-pub ahead of print date: 29 March 2021
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Local EPrints ID: 476183
URI: http://eprints.soton.ac.uk/id/eprint/476183
ISSN: 1757-790X
PURE UUID: 3a821e34-65a6-4746-bfe3-76f1745741e3
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Date deposited: 13 Apr 2023 16:44
Last modified: 17 Mar 2024 01:21
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Author:
Alexander Mitchell
Author:
Mitul Patel
Author:
Chloe Manning
Author:
Joseph Abbott
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