The University of Southampton
University of Southampton Institutional Repository

Natural antibody status in patients with Hashimoto's thyroiditis

Natural antibody status in patients with Hashimoto's thyroiditis
Natural antibody status in patients with Hashimoto's thyroiditis

Raised levels of circulating natural antibodies (NABS) have been found in association with systemic lupus erythematosus (SLE) and chronic active hepatitis (CAH), indicative of polyclonal B-cell activation associated with these relatively non-organ specific autoimmune diseases. This study examined the natural antibody response in the organ-specific autoimmune disease Hashimoto's thyroiditis. Serum samples obtained from 69 women with newly diagnosed Hashimoto's thyroiditis together with 64 controls were analysed for IgG and IgM NABS directed at DNA, actin, myoglobin, myosin, trinitrophenyl hapten (TNP) and tubulin as the NAB antigen panel using an established ELISA. The same technique was also used to estimate thyroglobulin and thyroid microsomal autoantibody activities. Compared to a reference panel of normal serum samples, 31 of the Hashimoto's samples showed a greater than 2SD elevation of IgG and/or IgM NABS against one or more of the panel antigens together with elevated IgG thyroglobulin and thyroid microsomal antibody levels. The cases positive for one or more of the NAB panel also showed a greater incidence of active Hashimoto's thyroiditis as indicated by the presence of antibodies directed against the thyroid specific antigens. The above findings suggest that raised levels of NABS are also a feature of this organ-specific autoimmune disease. The wide ranging NAB specificities involved are consistent with an underlying or epiphenomenal state of polyclonal B-cell activation.

Antibodies, Antinuclear/blood, Autoantibodies/blood, Case-Control Studies, Female, Humans, Immunity, Innate, Immunoglobulin G/blood, Immunoglobulin M/blood, Middle Aged, Muscle Proteins/immunology, Thyroid Gland/immunology, Thyroiditis, Autoimmune/immunology, Tubulin/immunology
0141-2760
9-20
Jasani, B
bb0b21a9-8542-42bf-9bbb-9c9f5fe88adf
Ternynck, T
3e8244e0-f552-4331-b6ba-94709d58df93
Lazarus, J H
76eae546-9960-4846-aabf-de07f75133bd
Phillips, D.I.W.
8f0a3c06-5a71-4344-8df0-d8f864e42524
Avrameas, S
0792e4d2-ef20-4ad1-b014-a0c80592a214
Parkes, A B
60c00765-a2d0-4bff-899e-a09b903c23e9
Jasani, B
bb0b21a9-8542-42bf-9bbb-9c9f5fe88adf
Ternynck, T
3e8244e0-f552-4331-b6ba-94709d58df93
Lazarus, J H
76eae546-9960-4846-aabf-de07f75133bd
Phillips, D.I.W.
8f0a3c06-5a71-4344-8df0-d8f864e42524
Avrameas, S
0792e4d2-ef20-4ad1-b014-a0c80592a214
Parkes, A B
60c00765-a2d0-4bff-899e-a09b903c23e9

Jasani, B, Ternynck, T, Lazarus, J H, Phillips, D.I.W., Avrameas, S and Parkes, A B (1999) Natural antibody status in patients with Hashimoto's thyroiditis. Journal of Clinical and Laboratory Immunology, 51 (1), 9-20.

Record type: Article

Abstract

Raised levels of circulating natural antibodies (NABS) have been found in association with systemic lupus erythematosus (SLE) and chronic active hepatitis (CAH), indicative of polyclonal B-cell activation associated with these relatively non-organ specific autoimmune diseases. This study examined the natural antibody response in the organ-specific autoimmune disease Hashimoto's thyroiditis. Serum samples obtained from 69 women with newly diagnosed Hashimoto's thyroiditis together with 64 controls were analysed for IgG and IgM NABS directed at DNA, actin, myoglobin, myosin, trinitrophenyl hapten (TNP) and tubulin as the NAB antigen panel using an established ELISA. The same technique was also used to estimate thyroglobulin and thyroid microsomal autoantibody activities. Compared to a reference panel of normal serum samples, 31 of the Hashimoto's samples showed a greater than 2SD elevation of IgG and/or IgM NABS against one or more of the panel antigens together with elevated IgG thyroglobulin and thyroid microsomal antibody levels. The cases positive for one or more of the NAB panel also showed a greater incidence of active Hashimoto's thyroiditis as indicated by the presence of antibodies directed against the thyroid specific antigens. The above findings suggest that raised levels of NABS are also a feature of this organ-specific autoimmune disease. The wide ranging NAB specificities involved are consistent with an underlying or epiphenomenal state of polyclonal B-cell activation.

This record has no associated files available for download.

More information

Published date: 15 January 1999
Keywords: Antibodies, Antinuclear/blood, Autoantibodies/blood, Case-Control Studies, Female, Humans, Immunity, Innate, Immunoglobulin G/blood, Immunoglobulin M/blood, Middle Aged, Muscle Proteins/immunology, Thyroid Gland/immunology, Thyroiditis, Autoimmune/immunology, Tubulin/immunology

Identifiers

Local EPrints ID: 476357
URI: http://eprints.soton.ac.uk/id/eprint/476357
ISSN: 0141-2760
PURE UUID: 2e21007d-b87a-4ebd-8d02-958a081596d4

Catalogue record

Date deposited: 19 Apr 2023 16:46
Last modified: 19 Apr 2023 16:46

Export record

Contributors

Author: B Jasani
Author: T Ternynck
Author: J H Lazarus
Author: D.I.W. Phillips
Author: S Avrameas
Author: A B Parkes

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×