READ ME File For 'Computational model for metformin transfer in the human placenta'

Dataset DOI: https://doi.org/10.5258/SOTON/D2561 

Date that the file was created: April, 2023

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GENERAL INFORMATION
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ReadMe Author: Bram Sengers, University of Southampton

Date of data collection: 2020-21

Information about geographic location of data collection: Southampton, UK

Related projects: BBSRC [BB/R002762/1]


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SHARING/ACCESS INFORMATION
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Licenses/restrictions placed on the data, or limitations of reuse: Attribution (CC BY 4.0)

This dataset supports the publication:
AUTHORS: Emma M. Lofthouse, Jane Cleal, Rohan M. Lewis, 
Bram G. Sengers
TITLE: Computational modelling of paracellular diffusion and OCT3 mediated transport of metformin in the perfused human placenta.
JOURNAL: Journal of Pharmaceutical Sciences
PAPER DOI IF KNOWN:


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DATA & FILE OVERVIEW
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This dataset contains a zip file with the Matlab files and experimental data used for the paper.

The following are the main files to run for the bidirectional perfusion experiment and OCT3 experiment respectively and can be found in the 'Metformin model' folder:

-> Run_Bidirectional_exp.m

-> Run_OCT3_exp.m


The creatine model can be run using the following file found in the separate 'Creatinine model' folder

-> Run_OCT3_exp_creatinine.m


The following files have been used to generate analytical functions for the carrier based transporter models with multiple substrates:

-> OCT3: genfuncasymmetric3substr.m
-> SERT: genfuncSERT_2substr.m


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METHODOLOGICAL INFORMATION
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Software used: Matlab 2018a