Clinical applications of remote ischaemic preconditioning in native and transplant acute kidney injury
Clinical applications of remote ischaemic preconditioning in native and transplant acute kidney injury
Ischaemia-reperfusion (IR) injury is a composite of the injury sustained during a period of reduced or absent blood flow to a tissue or organ and the additional insult sustained upon reperfusion that limits the amount of tissue that can be salvaged. IR injury plays a central role in both native and transplant acute kidney injury (AKI). Native AKI is associated with increased morbidity and mortality in hospital inpatients, and transplant AKI contributes to graft dysfunction, ultimately limiting graft longevity. In this review, we discuss the potential therapeutic benefits of a cost-effective and low-risk intervention, remote ischaemic preconditioning (RIPC), and its applicability in the prevention and reduction of AKI.
Acute Kidney Injury/epidemiology, Animals, Global Health, Graft Rejection/complications, Humans, Incidence, Ischemic Preconditioning/methods, Organ Transplantation/adverse effects, Survival Rate/trends
1749-1759
Veighey, Kristin
2adbaf5c-141a-44bd-a7eb-faf14e0ca251
MacAllister, Raymond
9f4b26b2-72e1-4ccf-9338-362d6193085b
October 2015
Veighey, Kristin
2adbaf5c-141a-44bd-a7eb-faf14e0ca251
MacAllister, Raymond
9f4b26b2-72e1-4ccf-9338-362d6193085b
Veighey, Kristin and MacAllister, Raymond
(2015)
Clinical applications of remote ischaemic preconditioning in native and transplant acute kidney injury.
Pediatric Nephrology, 30 (10), .
(doi:10.1007/s00467-014-2965-6).
Abstract
Ischaemia-reperfusion (IR) injury is a composite of the injury sustained during a period of reduced or absent blood flow to a tissue or organ and the additional insult sustained upon reperfusion that limits the amount of tissue that can be salvaged. IR injury plays a central role in both native and transplant acute kidney injury (AKI). Native AKI is associated with increased morbidity and mortality in hospital inpatients, and transplant AKI contributes to graft dysfunction, ultimately limiting graft longevity. In this review, we discuss the potential therapeutic benefits of a cost-effective and low-risk intervention, remote ischaemic preconditioning (RIPC), and its applicability in the prevention and reduction of AKI.
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Published date: October 2015
Keywords:
Acute Kidney Injury/epidemiology, Animals, Global Health, Graft Rejection/complications, Humans, Incidence, Ischemic Preconditioning/methods, Organ Transplantation/adverse effects, Survival Rate/trends
Identifiers
Local EPrints ID: 476505
URI: http://eprints.soton.ac.uk/id/eprint/476505
ISSN: 0931-041X
PURE UUID: d4e9ce54-843f-42fd-95df-7b9c747f8af5
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Date deposited: 04 May 2023 17:01
Last modified: 21 Jun 2024 01:54
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Author:
Raymond MacAllister
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