Metal–enzyme hybrid catalysts in cascade and multicomponent processes

San, Boi Hoa, Gusthart, Jessica S, Lee, Seung Seo and Kim, Kyeong Kyu (2018) Metal–enzyme hybrid catalysts in cascade and multicomponent processes. In, Diéguez, Montserrat, Bäckvall, Jan-E. and Pàmies, Oscar (eds.) Artificial Metalloenzymes and MetalloDNAzymes in Catalysis: From Design to Applications. Wiley, pp. 321-351. (doi:10.1002/9783527804085.ch11).

Abstract

Chemical synthesis is generally completed through sequential multistep reactions with many reaction components and catalysts. However, intensive purification processes and low reaction yield in each step often make it difficult to obtain the desired efficiency within a given time period. To overcome these limitations, multicomponent cascade reactions are proposed, in which all reaction components are supplied in one pot, and reactions are carried out consecutively without producing intermediates. Metal–enzyme catalysts, a combination of a metallic catalyst and a biocatalyst, are particularly useful for this purpose. In this chapter, we introduce several examples of efficient metal–enzyme hybrid catalysts designed for multicomponent cascade processes in chemical synthesis. In addition, we describe the design strategy of the metal–enzyme catalysts and our current understanding of its reaction mechanism in theoretical and experimental aspects results. Finally, the potential of this process for scientific and industrial applications is discussed.

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Contributors

Author: Seung Seo Lee

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