Anthocyanins ameliorate obesity-associated metainflammation: preclinical and clinical evidence
Anthocyanins ameliorate obesity-associated metainflammation: preclinical and clinical evidence
The growing rates of obesity worldwide call for intervention strategies to help control the pathophysiological consequences of weight gain. The use of natural foods and bioactive compounds has been suggested as such a strategy because of their recognized antioxidant and anti-inflammatory properties. For example, polyphenols, especially anthocyanins, are candidates for managing obesity and its related metabolic disorders. Obesity is well known for the presence of metainflammation, which has been labeled as an inflammatory activation that leads to a variety of metabolic disorders, usually related to increased oxidative stress. Considering this, anthocyanins may be promising natural compounds able to modulate several intracellular mechanisms, mitigating oxidative stress and metainflammation. A wide variety of foods and extracts rich in anthocyanins have become the focus of research in the field of obesity. Here, we bring together the current knowledge regarding the use of anthocyanins as an intervention tested in vitro, in vivo, and in clinical trials to modulate metainflammation. Most recent research applies a wide variety of extracts and natural sources of anthocyanins, in diverse experimental models, which represents a limitation of the research field. However, the literature is sufficiently consistent to establish that the in-depth molecular analysis of gut microbiota, insulin signaling, TLR4-triggered inflammation, and oxidative stress pathways reveals their modulation by anthocyanins. These targets are interconnected at the cellular level and interact with one another, leading to obesity-associated metainflammation. Thus, the positive findings with anthocyanins observed in preclinical models might directly relate to the positive outcomes in clinical studies. In summary and based on the entirety of the relevant literature, anthocyanins can mitigate obesity-related perturbations in gut microbiota, insulin resistance, oxidative stress and inflammation and therefore may contribute as a therapeutic tool in people living with obesity.
Bioactive compounds, Gut microbiota, Insulin resistance, Obesity, Oxidative stress, Polyphenols, TLR4/NFκB pathway
50-70
Santamarina, Aline B
8415c2a7-4088-4ca5-ac77-4ea70796df49
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Estadella, Deborah
30b871bb-76fb-4f20-a191-7308962c925c
Pisani, Luciana P
8fbf92c9-d0b9-4977-a23e-aa971e31f75d
June 2023
Santamarina, Aline B
8415c2a7-4088-4ca5-ac77-4ea70796df49
Calder, Philip
1797e54f-378e-4dcb-80a4-3e30018f07a6
Estadella, Deborah
30b871bb-76fb-4f20-a191-7308962c925c
Pisani, Luciana P
8fbf92c9-d0b9-4977-a23e-aa971e31f75d
Santamarina, Aline B, Calder, Philip, Estadella, Deborah and Pisani, Luciana P
(2023)
Anthocyanins ameliorate obesity-associated metainflammation: preclinical and clinical evidence.
Nutrition Research, 114, .
(doi:10.1016/j.nutres.2023.04.004).
Abstract
The growing rates of obesity worldwide call for intervention strategies to help control the pathophysiological consequences of weight gain. The use of natural foods and bioactive compounds has been suggested as such a strategy because of their recognized antioxidant and anti-inflammatory properties. For example, polyphenols, especially anthocyanins, are candidates for managing obesity and its related metabolic disorders. Obesity is well known for the presence of metainflammation, which has been labeled as an inflammatory activation that leads to a variety of metabolic disorders, usually related to increased oxidative stress. Considering this, anthocyanins may be promising natural compounds able to modulate several intracellular mechanisms, mitigating oxidative stress and metainflammation. A wide variety of foods and extracts rich in anthocyanins have become the focus of research in the field of obesity. Here, we bring together the current knowledge regarding the use of anthocyanins as an intervention tested in vitro, in vivo, and in clinical trials to modulate metainflammation. Most recent research applies a wide variety of extracts and natural sources of anthocyanins, in diverse experimental models, which represents a limitation of the research field. However, the literature is sufficiently consistent to establish that the in-depth molecular analysis of gut microbiota, insulin signaling, TLR4-triggered inflammation, and oxidative stress pathways reveals their modulation by anthocyanins. These targets are interconnected at the cellular level and interact with one another, leading to obesity-associated metainflammation. Thus, the positive findings with anthocyanins observed in preclinical models might directly relate to the positive outcomes in clinical studies. In summary and based on the entirety of the relevant literature, anthocyanins can mitigate obesity-related perturbations in gut microbiota, insulin resistance, oxidative stress and inflammation and therefore may contribute as a therapeutic tool in people living with obesity.
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Accepted/In Press date: 10 April 2023
e-pub ahead of print date: 20 April 2023
Published date: June 2023
Additional Information:
Funding Information:
This work was supported by “ Fundação de Amparo à Pesquisa do Estado de São Paulo ” (FAPESP 2020/04448-0 ). L.P.P. receives a CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico fellowship ( 305725/2020-3 ).
Publisher Copyright:
© 2023 Elsevier Inc.
Keywords:
Bioactive compounds, Gut microbiota, Insulin resistance, Obesity, Oxidative stress, Polyphenols, TLR4/NFκB pathway
Identifiers
Local EPrints ID: 476797
URI: http://eprints.soton.ac.uk/id/eprint/476797
ISSN: 0271-5317
PURE UUID: 6f4d3418-d537-4eba-8f6f-f2fdc1a4dac6
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Date deposited: 16 May 2023 16:43
Last modified: 10 Apr 2024 04:07
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Author:
Aline B Santamarina
Author:
Deborah Estadella
Author:
Luciana P Pisani
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