Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination
Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination
The UK was the first place to Introduce meningococcal serogroup C conjugate (MCC) vaccines. From November, 1999, all people younger than 18 years, about 14 million individuals, were offered MCC immunisation. The uptake rate was more than 70% by November, 2000. We compared the carriage of meningococci in isolates we obtained from 14 064 students aged 15–17 years during vaccination in 1999, with those from 16 583 students of the same age surveyed 1 year later. Carriage of serogroup C meningococci was reduced by 66% (p=0·004). Our results show that MCC vaccines protect against carriage of meningococci that express serogroup C polysaccharide capsules.
1829-1830
Maiden, Martin C. J.
7b06ed51-759c-496d-a306-04d1c0bca1fa
Stuart, James M.
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Clarke, Stuart C.
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25 May 2002
Maiden, Martin C. J.
7b06ed51-759c-496d-a306-04d1c0bca1fa
Stuart, James M.
c0ddb371-9c44-4e79-bbe0-ee32254241a0
Clarke, Stuart C.
f7d7f7a2-4b1f-4b36-883a-0f967e73fb17
Maiden, Martin C. J., Stuart, James M. and Clarke, Stuart C.
(2002)
Carriage of serogroup C meningococci 1 year after meningococcal C conjugate polysaccharide vaccination.
The Lancet, 359 (9320), .
Abstract
The UK was the first place to Introduce meningococcal serogroup C conjugate (MCC) vaccines. From November, 1999, all people younger than 18 years, about 14 million individuals, were offered MCC immunisation. The uptake rate was more than 70% by November, 2000. We compared the carriage of meningococci in isolates we obtained from 14 064 students aged 15–17 years during vaccination in 1999, with those from 16 583 students of the same age surveyed 1 year later. Carriage of serogroup C meningococci was reduced by 66% (p=0·004). Our results show that MCC vaccines protect against carriage of meningococci that express serogroup C polysaccharide capsules.
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Published date: 25 May 2002
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Local EPrints ID: 477091
URI: http://eprints.soton.ac.uk/id/eprint/477091
ISSN: 0140-6736
PURE UUID: e25e8263-3218-49d8-993f-ab21fe6c510f
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Date deposited: 25 May 2023 16:49
Last modified: 12 Mar 2024 02:44
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Author:
Martin C. J. Maiden
Author:
James M. Stuart
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