Different detectors used with SFC
Different detectors used with SFC
In addition to the common quality attributes of an SFC separation, i.e., resolution, peak shape, repeatability, and transferability, there are other detector-related attributes that need to be recognized for method development or routine operation. For example, response (peak height) and sensitivity required for the analyte and associated impurities will ultimately affect the SFC-detection method choice. Understanding the details of how these detectors operate and why they are desirable for use with SFC is an important part of making the most appropriate choice when considering method development using SFC. Herein, we emphasize the use of SFC with several common detectors. These different detection approaches are a significant testament to the importance of SFC as an analytical tool for many pharmaceutical lab applications.
CAD, ELSD, Hyphenation, Mass spectrometry, UV
299-324
Langley, G. John
7ac80d61-b91d-4261-ad17-255f94ea21ea
Cancho-Gonzalez, Sergio
1fc211b0-5c0f-4435-8935-51eef7f2f212
Herniman, Julie M.
530b1a36-1386-4602-8df7-defa6eb3512b
Langley, G. John
7ac80d61-b91d-4261-ad17-255f94ea21ea
Cancho-Gonzalez, Sergio
1fc211b0-5c0f-4435-8935-51eef7f2f212
Herniman, Julie M.
530b1a36-1386-4602-8df7-defa6eb3512b
Langley, G. John, Cancho-Gonzalez, Sergio and Herniman, Julie M.
(2022)
Different detectors used with SFC.
In,
Separation Science and Technology.
(Separation Science and Technology (New York), 14)
Elsevier Inc., .
(doi:10.1016/B978-0-323-88487-7.00002-4).
Record type:
Book Section
Abstract
In addition to the common quality attributes of an SFC separation, i.e., resolution, peak shape, repeatability, and transferability, there are other detector-related attributes that need to be recognized for method development or routine operation. For example, response (peak height) and sensitivity required for the analyte and associated impurities will ultimately affect the SFC-detection method choice. Understanding the details of how these detectors operate and why they are desirable for use with SFC is an important part of making the most appropriate choice when considering method development using SFC. Herein, we emphasize the use of SFC with several common detectors. These different detection approaches are a significant testament to the importance of SFC as an analytical tool for many pharmaceutical lab applications.
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e-pub ahead of print date: 2 December 2022
Additional Information:
Funding Information:
The authors would like to thank Dr. Paul Ferguson (AstraZeneca) for editorial assistance.
Keywords:
CAD, ELSD, Hyphenation, Mass spectrometry, UV
Identifiers
Local EPrints ID: 477143
URI: http://eprints.soton.ac.uk/id/eprint/477143
ISSN: 1877-1718
PURE UUID: d8d72d14-18fb-45aa-8aa5-98a41c44c54b
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Date deposited: 30 May 2023 16:38
Last modified: 06 Jun 2024 01:37
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Author:
Sergio Cancho-Gonzalez
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