The gut microbiota in chronic obstructive pulmonary disease varies by CT-verified emphysema status
The gut microbiota in chronic obstructive pulmonary disease varies by CT-verified emphysema status
Background and aim The association of the gut microbiota to chronic obstructive pulmonary disease (COPD) phenotypes is underexplored. We aimed to compare stool samples from COPD patients and healthy controls and relate findings to common COPD phenotypes. Methods Single-centre case-control study with 62 current and former smoking COPD patients and 49 controls. DNA was extracted from stool samples, and the V3V4-region of the bacterial 16S-rRNA gene was sequenced. Emphysema was defined based on thoracic computed tomography (CT thorax) low attenuating areas ≥/
Rotevatn, Anders
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Eagan, Tomas
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Tangedal, Solveig
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Husebø, Gunnar
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Ostridge, Kristoffer
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Nielsen, Rune
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Rotevatn, Anders
dbf1097c-acc2-422b-9b08-0ffa3fd67816
Eagan, Tomas
701c6eb5-f80d-4930-9df8-bc13508d83fe
Tangedal, Solveig
6a99bfa5-229a-406b-884f-d62c24f686d3
Husebø, Gunnar
0df7a3ee-ffc2-424a-9502-ab2d1cf8ba64
Ostridge, Kristoffer
d2271bae-b078-4390-8919-8f8c0e20542c
Nielsen, Rune
c1c0e4ee-00b3-41d3-92ea-9d6f75413116
Rotevatn, Anders, Eagan, Tomas, Tangedal, Solveig, Husebø, Gunnar, Ostridge, Kristoffer and Nielsen, Rune
(2023)
The gut microbiota in chronic obstructive pulmonary disease varies by CT-verified emphysema status.
Zenodo
doi:10.5061/dryad.m37pvmd6c
[Dataset]
Abstract
Background and aim The association of the gut microbiota to chronic obstructive pulmonary disease (COPD) phenotypes is underexplored. We aimed to compare stool samples from COPD patients and healthy controls and relate findings to common COPD phenotypes. Methods Single-centre case-control study with 62 current and former smoking COPD patients and 49 controls. DNA was extracted from stool samples, and the V3V4-region of the bacterial 16S-rRNA gene was sequenced. Emphysema was defined based on thoracic computed tomography (CT thorax) low attenuating areas ≥/
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Published date: 22 May 2023
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Local EPrints ID: 477235
URI: http://eprints.soton.ac.uk/id/eprint/477235
PURE UUID: 4fef51aa-4982-43ce-9190-41bfae5c22ab
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Date deposited: 01 Jun 2023 16:52
Last modified: 04 Jan 2024 04:44
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Contributors
Creator:
Anders Rotevatn
Creator:
Tomas Eagan
Creator:
Solveig Tangedal
Creator:
Gunnar Husebø
Creator:
Kristoffer Ostridge
Creator:
Rune Nielsen
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