The effects of stimulant and non-stimulant medications on the autonomic nervous system (ANS) functioning in people with ADHD: A systematic review and meta-analysis: a systematic review and meta-analysis
The effects of stimulant and non-stimulant medications on the autonomic nervous system (ANS) functioning in people with ADHD: A systematic review and meta-analysis: a systematic review and meta-analysis
We carried out a systematic review and meta-analysis to investigate the effects of stimulant and non-stimulant medications on autonomic functioning in people with ADHD (PROSPERO: CRD42020212439). We searched (9th August 2021) PsycInfo, MEDLINE, EMBASE, Web of Science and The Cochrane Library, for randomised and non-randomised studies reporting indices of autonomic activity, (electrodermal, pupillometry and cardiac), pre- and post-medication exposure in people meeting DSM/ICD criteria for ADHD. In the narrative syntheses, we included 5 electrodermal studies, 1 pupillometry study and 57 studies investigating heart rate and blood pressure. In the meta-analyses, 29 studies were included on blood pressure and 32 on heart rate. Administration of stimulants, and to a lesser degree, non-stimulants increased heart rate and blood pressure in people with ADHD. Similarly, an upregulation of arousal, reflected in increased electrodermal activity and pupil diameter was observed following stimulant use. Yet, the methodological diversity of studies presented in this review reinforces the need for more standardised and rigorous research to fully understand the relationship between arousal, medication, and behaviour in ADHD.
ADHD, Arousal, Autonomic, Electrodermal activity, HRV, Heart rate, Medication, Non-stimulants, Pupillometry, Stimulants
104968
Idrees, Iman
7af0ed2d-3751-4d1d-bb4b-1b4a891372de
Bellato, Alessio
af2bf50d-431e-4fb2-b77f-5e8ee5a04409
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Groom, Madeleine J
0950cda7-451f-40c3-a4e2-e6df8629de55
1 January 2023
Idrees, Iman
7af0ed2d-3751-4d1d-bb4b-1b4a891372de
Bellato, Alessio
af2bf50d-431e-4fb2-b77f-5e8ee5a04409
Cortese, Samuele
53d4bf2c-4e0e-4c77-9385-218350560fdb
Groom, Madeleine J
0950cda7-451f-40c3-a4e2-e6df8629de55
Idrees, Iman, Bellato, Alessio, Cortese, Samuele and Groom, Madeleine J
(2023)
The effects of stimulant and non-stimulant medications on the autonomic nervous system (ANS) functioning in people with ADHD: A systematic review and meta-analysis: a systematic review and meta-analysis.
Neuroscience and Biobehavioral Reviews, 144 (1), , [104968].
(doi:10.1016/j.neubiorev.2022.104968).
Abstract
We carried out a systematic review and meta-analysis to investigate the effects of stimulant and non-stimulant medications on autonomic functioning in people with ADHD (PROSPERO: CRD42020212439). We searched (9th August 2021) PsycInfo, MEDLINE, EMBASE, Web of Science and The Cochrane Library, for randomised and non-randomised studies reporting indices of autonomic activity, (electrodermal, pupillometry and cardiac), pre- and post-medication exposure in people meeting DSM/ICD criteria for ADHD. In the narrative syntheses, we included 5 electrodermal studies, 1 pupillometry study and 57 studies investigating heart rate and blood pressure. In the meta-analyses, 29 studies were included on blood pressure and 32 on heart rate. Administration of stimulants, and to a lesser degree, non-stimulants increased heart rate and blood pressure in people with ADHD. Similarly, an upregulation of arousal, reflected in increased electrodermal activity and pupil diameter was observed following stimulant use. Yet, the methodological diversity of studies presented in this review reinforces the need for more standardised and rigorous research to fully understand the relationship between arousal, medication, and behaviour in ADHD.
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Accepted/In Press date: 19 November 2022
Published date: 1 January 2023
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Funding Information:
Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Publisher Copyright:
© 2022 The Authors
Keywords:
ADHD, Arousal, Autonomic, Electrodermal activity, HRV, Heart rate, Medication, Non-stimulants, Pupillometry, Stimulants
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Local EPrints ID: 477514
URI: http://eprints.soton.ac.uk/id/eprint/477514
ISSN: 0149-7634
PURE UUID: 0e2118a5-41e8-43fc-9a14-d71c084e8d22
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Date deposited: 07 Jun 2023 17:03
Last modified: 17 Mar 2024 03:37
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Author:
Iman Idrees
Author:
Alessio Bellato
Author:
Madeleine J Groom
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