Narrative review to capture patients' perceptions and opinions about non-response and response to biological therapy for severe asthma
Narrative review to capture patients' perceptions and opinions about non-response and response to biological therapy for severe asthma
Background: There are now many biological therapies to treat severe asthma. To assess which work best for which patient, we need to develop definitions of response. This narrative review aims to capture severe asthma patients' perceptions about non-response and response to biological therapy. Methods Four bibliographic databases were searched from inception to September 2021. Grey literature was searched with the involvement of patient representatives. A thematic approach was used for synthesis. No qualitative studies specifically explore patients' perspectives on response to biological therapy for severe asthma. Three papers and one published asthma patient interview were included. Relevant grey literature was included from online discussion forums, blogs and social media websites. Results Adult patients framed positive response to biological therapy in terms of reduced burden of disease and treatment. Both were multifaceted. Some patients experienced reduced benefit from biological therapy over time. There was a group of patients who described a limited response or non-response to biological therapy. This was framed within the context of continuing hospitalisation and oral corticosteroid treatment. The speed of onset of benefit was felt to be important by some. Conclusions Definitions of non-response and response need to be patient-centred, yet there is a complete lack of qualitative research focused on this topic. By combining relevant published and grey literature we have provided a description of adult patients' perceptions of response to biological therapy in severe asthma. We now need to understand the views of children and adolescents with severe asthma and their carers, and diverse patient experiences in real-world settings.
Adolescent, Adult, Asthma/drug therapy, Biological Therapy, Child, Humans, Qualitative Research
Coleman, Courtney
2680e0d6-69d4-4b13-bd44-1cf4c3566a55
Khaleva, Ekaterina
0143fad8-e8b7-4286-997b-368a23488ca8
Rattu, Anna
ea310926-604d-4307-9843-0bf7b30240e2
Frankemölle, Betty
76f5fdb2-c1dd-4d94-81af-fcbb4b8560ed
Nielsen, Hanna
e79081f6-7212-47e9-9cd2-17de6617e14f
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Williams, Clare
7218b86b-64f1-4317-b68b-115eb9542d86
the 3TR Respiratory Work Package
1 January 2023
Coleman, Courtney
2680e0d6-69d4-4b13-bd44-1cf4c3566a55
Khaleva, Ekaterina
0143fad8-e8b7-4286-997b-368a23488ca8
Rattu, Anna
ea310926-604d-4307-9843-0bf7b30240e2
Frankemölle, Betty
76f5fdb2-c1dd-4d94-81af-fcbb4b8560ed
Nielsen, Hanna
e79081f6-7212-47e9-9cd2-17de6617e14f
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Williams, Clare
7218b86b-64f1-4317-b68b-115eb9542d86
Coleman, Courtney, Khaleva, Ekaterina, Rattu, Anna and Roberts, Graham
,
the 3TR Respiratory Work Package
(2023)
Narrative review to capture patients' perceptions and opinions about non-response and response to biological therapy for severe asthma.
European Respiratory Journal, 61 (1), [2200837].
(doi:10.1183/13993003.00837-2022).
Abstract
Background: There are now many biological therapies to treat severe asthma. To assess which work best for which patient, we need to develop definitions of response. This narrative review aims to capture severe asthma patients' perceptions about non-response and response to biological therapy. Methods Four bibliographic databases were searched from inception to September 2021. Grey literature was searched with the involvement of patient representatives. A thematic approach was used for synthesis. No qualitative studies specifically explore patients' perspectives on response to biological therapy for severe asthma. Three papers and one published asthma patient interview were included. Relevant grey literature was included from online discussion forums, blogs and social media websites. Results Adult patients framed positive response to biological therapy in terms of reduced burden of disease and treatment. Both were multifaceted. Some patients experienced reduced benefit from biological therapy over time. There was a group of patients who described a limited response or non-response to biological therapy. This was framed within the context of continuing hospitalisation and oral corticosteroid treatment. The speed of onset of benefit was felt to be important by some. Conclusions Definitions of non-response and response need to be patient-centred, yet there is a complete lack of qualitative research focused on this topic. By combining relevant published and grey literature we have provided a description of adult patients' perceptions of response to biological therapy in severe asthma. We now need to understand the views of children and adolescents with severe asthma and their carers, and diverse patient experiences in real-world settings.
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Accepted/In Press date: 15 August 2022
Published date: 1 January 2023
Additional Information:
Funding Information:
Acknowledgements: We would like to acknowledge the support of 3TR in funding the development of this narrative review. We would like to thank Paula Sands (University of Southampton, Southampton, UK) for her assistance in optimising the search strategy. We would like to thank Theo Schilpzand (respiratory representative on the Patient Advisory Board for 3TR) for reviewing the manuscript from a patient’s perspective.
Funding Information:
The 3TR project is funded by the Innovative Medicines Initiative (IMI) 2 Joint Undertaking (JU) under grant agreement number 831434. The JU receives support from the European Union's Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). Disclaimer: Content of this publication reflects only the authors' view and the JU is not responsible for any use that may be made of the information it contains. The funder had no role in the design, conduct or write up of the narrative review or decision to publish. Further details about the 3TR project and IMI funding programme are available on their websites: www.3tr-imi.eu and www.imi.europa.eu. Funding information for this article has been deposited with the Crossref Funder Registry.
Funding Information:
Conflict of interest: All authors report that funding was received to support this work by the European Lung Foundation (ELF) from European Commission’s Innovative Medicines Initiative 2 Joint Undertaking under grant agreement number 831434 (3TR). C. Coleman and C. Williams are employees of the ELF. There are no further disclosures.
Publisher Copyright:
Copyright © The authors 2023.
Keywords:
Adolescent, Adult, Asthma/drug therapy, Biological Therapy, Child, Humans, Qualitative Research
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Local EPrints ID: 477520
URI: http://eprints.soton.ac.uk/id/eprint/477520
ISSN: 0903-1936
PURE UUID: c0fe3299-4732-4a95-9cb0-fed4ee1b6abb
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Date deposited: 07 Jun 2023 17:09
Last modified: 18 Mar 2024 03:57
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Contributors
Author:
Courtney Coleman
Author:
Ekaterina Khaleva
Author:
Anna Rattu
Author:
Betty Frankemölle
Author:
Hanna Nielsen
Author:
Clare Williams
Corporate Author: the 3TR Respiratory Work Package
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