Nutrient trajectories during infancy and their associations with childhood neurodevelopment
Nutrient trajectories during infancy and their associations with childhood neurodevelopment
Purpose: To examine the associations between infants' dietary nutrient trajectories and subsequent neurodevelopment during childhood in the Growing Up in Singapore Towards healthy Outcomes study.
Methods: One-day food records were collected at ages 6, 9 and 12 months, whilst Bayley Scales of Infant and Toddler Development-III and Kaufman Brief Intelligence Test-2 were conducted at ages 24 and 54 months respectively. Nutrient trajectories were constructed using multi-level mixed modelling and associations with neurodevelopment (24 months: n = 484; 54 months: n = 444) were examined using adjusted multivariable linear regression.
Results: At age 24 months, higher protein intake (at 6 months) and increasing rate of intake (from 6 to 12 months) were associated with higher fine motor score [β = 0.17 SD (95% CI 0.03, 0.31) and 0.62 SD (0.10, 1.14) respectively]. Higher fat intake was associated with higher receptive language score [0.04 SD (0.003, 0.07)], but increasing rate of intake was associated with lower expressive language [- 0.20 SD (- 0.39, - 0.01)] and fine motor [- 0.29 SD (- 0.48, - 0.10)] scores. Higher carbohydrate intake was associated with lower gross motor score [- 0.07 SD (- 0.14, - 0.005)], but increasing rate of intake was associated with higher receptive language [0.44 SD (0.08, 0.81)] and fine motor [0.56 SD (0.18, 0.93)] scores. Increasing rate of dietary fibre intake was associated with higher fine motor scores [0.63 SD (0.16, 1.10)]. No significant associations were observed with neurodevelopment at 54 months.
Conclusion: Our findings provide greater understanding of how nutrition over time could have varying effects on child neurodevelopment.
Cognition, Infant nutrient trajectories, Language, Motor development, Neurodevelopment
2429-2439
Toh, Jia Ying
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Cai, Shirong
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Lim, Shan Xuan
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Pang, Wei Wei
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Godfrey, Keith M.
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Shek, Lynette P.
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Tan, Kok Hian
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Yap, Fabian
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Lee, Yung Seng
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Chong, Yap-Seng
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Eriksson, Johan G.
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Broekman, Birit F.P.
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Rifkin-Graboi, Anne
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Chong, Mary F.F.
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September 2023
Toh, Jia Ying
bae40ae7-536e-451c-a758-b2b8674681ac
Cai, Shirong
0d23d2c5-889d-4f33-887f-b52e3d341ba4
Lim, Shan Xuan
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Pang, Wei Wei
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Godfrey, Keith M.
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Shek, Lynette P.
9a77403c-0e0c-4536-a5ad-628ce94b279a
Tan, Kok Hian
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Yap, Fabian
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Lee, Yung Seng
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Chong, Yap-Seng
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Eriksson, Johan G.
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Broekman, Birit F.P.
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Rifkin-Graboi, Anne
af440bed-c49d-4417-93b3-2243c8a2f1a8
Chong, Mary F.F.
1e188259-b1ab-4448-9e65-5b6a0fd99502
Toh, Jia Ying, Cai, Shirong, Lim, Shan Xuan, Pang, Wei Wei, Godfrey, Keith M., Shek, Lynette P., Tan, Kok Hian, Yap, Fabian, Lee, Yung Seng, Chong, Yap-Seng, Eriksson, Johan G., Broekman, Birit F.P., Rifkin-Graboi, Anne and Chong, Mary F.F.
(2023)
Nutrient trajectories during infancy and their associations with childhood neurodevelopment.
European Journal of Nutrition, 62 (6), .
(doi:10.1007/s00394-023-03164-2).
Abstract
Purpose: To examine the associations between infants' dietary nutrient trajectories and subsequent neurodevelopment during childhood in the Growing Up in Singapore Towards healthy Outcomes study.
Methods: One-day food records were collected at ages 6, 9 and 12 months, whilst Bayley Scales of Infant and Toddler Development-III and Kaufman Brief Intelligence Test-2 were conducted at ages 24 and 54 months respectively. Nutrient trajectories were constructed using multi-level mixed modelling and associations with neurodevelopment (24 months: n = 484; 54 months: n = 444) were examined using adjusted multivariable linear regression.
Results: At age 24 months, higher protein intake (at 6 months) and increasing rate of intake (from 6 to 12 months) were associated with higher fine motor score [β = 0.17 SD (95% CI 0.03, 0.31) and 0.62 SD (0.10, 1.14) respectively]. Higher fat intake was associated with higher receptive language score [0.04 SD (0.003, 0.07)], but increasing rate of intake was associated with lower expressive language [- 0.20 SD (- 0.39, - 0.01)] and fine motor [- 0.29 SD (- 0.48, - 0.10)] scores. Higher carbohydrate intake was associated with lower gross motor score [- 0.07 SD (- 0.14, - 0.005)], but increasing rate of intake was associated with higher receptive language [0.44 SD (0.08, 0.81)] and fine motor [0.56 SD (0.18, 0.93)] scores. Increasing rate of dietary fibre intake was associated with higher fine motor scores [0.63 SD (0.16, 1.10)]. No significant associations were observed with neurodevelopment at 54 months.
Conclusion: Our findings provide greater understanding of how nutrition over time could have varying effects on child neurodevelopment.
Text
Infant diet and neurodevelopment_Manuscript_cleaned
- Accepted Manuscript
More information
Accepted/In Press date: 21 April 2023
e-pub ahead of print date: 28 April 2023
Published date: September 2023
Additional Information:
Funding Information:
We would like to thank the participants for their contributions to this study. We would also like to thank and acknowledge the GUSTO study group. The GUSTO study group includes Allan Sheppard, Amutha Chinnadurai, Anne Eng Neo Goh, Anne Rifkin-Graboi, Anqi Qiu, Arijit Biswas, Bee Wah Lee, Birit Froukje Philipp Broekman, Boon Long Quah, Chai Kiat Chng, Cheryl Shufen Ngo, Choon Looi Bong, Christiani Jeyakumar Henry, Daniel Yam Thiam Goh, Doris Ngiuk Lan Loh, Fabian Kok Peng Yap, George Seow Heong Yeo, Helen Yu Chen, Hugo P. S. van Bever, Iliana Magiati, Inez Bik Yun Wong, Ivy Yee-Man Lau, Jeevesh Kapur, Jenny L. Richmond, Jerry Kok Yen Chan, Joanna Dawn Holbrook, Joshua J. Gooley, Keith M. Godfrey, Kenneth Yung Chiang Kwek, Kok Hian Tan, Krishnamoorthy Naiduvaje, Leher Singh, Lin Su, Lourdes Mary Daniel, Lynette Pei-Chi Shek, Marielle V. Fortier, Mark Hanson, Mary Foong-Fong Chong, Mary Rauff, Mei Chien Chua, Michael J. Meaney, Mya Thway Tint, Neerja Karnani, Ngee Lek, Oon Hoe Teoh, P. C. Wong, Peter David Gluckman, Pratibha Keshav Agarwal, Rob Martinus van Dam, Salome A. Rebello, Seang Mei Saw, Shang Chee Chong, Shirong Cai, Shu-E Soh, Sok Bee Lim, Stephen Chin-Ying Hsu, Victor Samuel Rajadurai, Walter Stunkel, Wee Meng Han, Wei Pang, Yap Seng Chong, Yin Bun Cheung, Yiong Huak Chan and Yung Seng Lee.
Funding Information:
The GUSTO cohort study was funded by the Singapore National Research Foundation’s Translational and Clinical Research (TCR) Flagship Programme and was administered by the Singapore Ministry of Health’s National Medical Research Council (NMRC), Singapore—NMRC/TCR/004-NUS/2008; NMRC/TCR/012-NUHS/2014. Additional funding was given by the Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore. KMG is supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator NF-SI-0515-10042), NIHR Southampton 1000DaysPlus Global Nutrition Research Group (17/63/154) and NIHR Southampton Biomedical Research Centre (IS-BRC-1215-20004), the British Heart Foundation (RG/15/17/3174) and by the European Union (Erasmus + Programme Early Nutrition eAcademy Southeast Asia-573651-EPP-1-2016-1-DE-EPPKA2-CBHE-JP and ImpENSA).
Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.
Keywords:
Cognition, Infant nutrient trajectories, Language, Motor development, Neurodevelopment
Identifiers
Local EPrints ID: 477585
URI: http://eprints.soton.ac.uk/id/eprint/477585
ISSN: 1436-6207
PURE UUID: d7c557d4-4650-49f3-a581-e9a7d25add60
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Date deposited: 08 Jun 2023 16:56
Last modified: 15 Aug 2024 01:33
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Contributors
Author:
Jia Ying Toh
Author:
Shirong Cai
Author:
Shan Xuan Lim
Author:
Wei Wei Pang
Author:
Lynette P. Shek
Author:
Kok Hian Tan
Author:
Fabian Yap
Author:
Yung Seng Lee
Author:
Yap-Seng Chong
Author:
Johan G. Eriksson
Author:
Birit F.P. Broekman
Author:
Anne Rifkin-Graboi
Author:
Mary F.F. Chong
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