Zwitterionic sulfhydryl Sulfobetaine stabilized platinum nanoparticles for ernhanced Dopamine detection and antitumor ability
Zwitterionic sulfhydryl Sulfobetaine stabilized platinum nanoparticles for ernhanced Dopamine detection and antitumor ability
Herein, three kinds of molecules were used to modify the surface of platinum nanoparticles (Pt NPs) to tune their surface charge. Zwitterionic thiol-functionalized sulfobetaine (SH-SB) stabilized Pt NPs (SH-SB/Pt NPs) had the highest oxidase activity and peroxidase activity in the prepared platinum nanozymes due to the generation of reactive oxygen species. In addition, a colorimetric dopamine detection method was established based on the peroxidase activity of SH-SB/Pt NPs. This method had a wide range (0-120 μM), a low detection limit (0.244 μM), and high specificity. More importantly, SH-SB/Pt NPs displayed little hemolysis and good stability in the presence of proteins. SH-SB/Pt NPs demonstrated high cytotoxicity in vitro and good antitumor ability in vivo, which was attributed to the photothermal conversion ability of SH-SB/Pt NPs and the generation of reactive oxygen species in the acidic environment. The surface modification of nanozymes using zwitterionic molecules opens a new method to improve the catalytic activity and antitumor ability of nanozymes.
antitumor, detection, dopamine, nanozyme, zwitterionic
55201-55216
Li, Ruyu
a7457a3c-c6b0-4eb4-87eb-e3720ebe7a59
Fan, Liyuan
6d31707e-7d87-4923-8c6a-5ff5e6165d93
Chen, Shengfu
1dd723db-42b2-4df0-be13-ae8555a4b946
Wang, Longgang
fa6e2c69-1986-4161-b285-774fb453e124
Cui, Yanshuai
7aaf9332-7fca-4721-a151-0c599df41405
Ma, Guanglong
4ba2ed72-fcf8-4116-8548-6d4774a80934
Zhang, Xiaoyu
c3181da9-f55f-4fd3-a5c8-0fa12d339259
Liu, Zhiwei
2cccd24d-8826-49ea-8884-862a0bcf6e10
2 December 2022
Li, Ruyu
a7457a3c-c6b0-4eb4-87eb-e3720ebe7a59
Fan, Liyuan
6d31707e-7d87-4923-8c6a-5ff5e6165d93
Chen, Shengfu
1dd723db-42b2-4df0-be13-ae8555a4b946
Wang, Longgang
fa6e2c69-1986-4161-b285-774fb453e124
Cui, Yanshuai
7aaf9332-7fca-4721-a151-0c599df41405
Ma, Guanglong
4ba2ed72-fcf8-4116-8548-6d4774a80934
Zhang, Xiaoyu
c3181da9-f55f-4fd3-a5c8-0fa12d339259
Liu, Zhiwei
2cccd24d-8826-49ea-8884-862a0bcf6e10
Li, Ruyu, Fan, Liyuan, Chen, Shengfu, Wang, Longgang, Cui, Yanshuai, Ma, Guanglong, Zhang, Xiaoyu and Liu, Zhiwei
(2022)
Zwitterionic sulfhydryl Sulfobetaine stabilized platinum nanoparticles for ernhanced Dopamine detection and antitumor ability.
ACS Applied Materials and Interfaces, 14 (49), .
(doi:10.1021/acsami.2c15863).
Abstract
Herein, three kinds of molecules were used to modify the surface of platinum nanoparticles (Pt NPs) to tune their surface charge. Zwitterionic thiol-functionalized sulfobetaine (SH-SB) stabilized Pt NPs (SH-SB/Pt NPs) had the highest oxidase activity and peroxidase activity in the prepared platinum nanozymes due to the generation of reactive oxygen species. In addition, a colorimetric dopamine detection method was established based on the peroxidase activity of SH-SB/Pt NPs. This method had a wide range (0-120 μM), a low detection limit (0.244 μM), and high specificity. More importantly, SH-SB/Pt NPs displayed little hemolysis and good stability in the presence of proteins. SH-SB/Pt NPs demonstrated high cytotoxicity in vitro and good antitumor ability in vivo, which was attributed to the photothermal conversion ability of SH-SB/Pt NPs and the generation of reactive oxygen species in the acidic environment. The surface modification of nanozymes using zwitterionic molecules opens a new method to improve the catalytic activity and antitumor ability of nanozymes.
Text
Zwitterionic sulfhydryl sulfobetaine stabilized platinum nanoparticles for enhanced dopamine detection and anti-tumor ability
- Accepted Manuscript
More information
Accepted/In Press date: 14 November 2022
Published date: 2 December 2022
Additional Information:
Funding Information:
The authors appreciate financial support from the Science and Technology Project of Hebei Education Department (QN2022124), the Natural Science Foundation of Hebei Province (B2017203229, H2022203004), the Subsidy for Hebei Key Laboratory of Applied Chemistry after Operation Performance (22567616H), the Key Program of Hebei University of Environmental Engineering (2020ZRZD02), the Science and Technology Support Program of Qinhuangdao (202101A007, 201902A191), the National Nature Science Foundation of China (21674092, 21975216 and 21474085), and The Zhejiang Provincial Natural Science Foundation of China (LZ20B040001).
Publisher Copyright:
© 2022 American Chemical Society.
Keywords:
antitumor, detection, dopamine, nanozyme, zwitterionic
Identifiers
Local EPrints ID: 477604
URI: http://eprints.soton.ac.uk/id/eprint/477604
ISSN: 1944-8244
PURE UUID: 0e03bed3-a3fa-43c7-8303-402728b4325f
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Date deposited: 09 Jun 2023 16:34
Last modified: 12 Nov 2024 05:02
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Contributors
Author:
Ruyu Li
Author:
Liyuan Fan
Author:
Shengfu Chen
Author:
Longgang Wang
Author:
Yanshuai Cui
Author:
Guanglong Ma
Author:
Xiaoyu Zhang
Author:
Zhiwei Liu
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