Long-circulation zwitterionic dendrimer nanodrugs for phototherapy of tumors
Long-circulation zwitterionic dendrimer nanodrugs for phototherapy of tumors
The development of stealth and effective antitumor nanodrugs has been drawing great attention. Herein, generation five poly(amide amine) dendrimer (G5 PAMAM) was modified by zwitterionic material carboxybetaine methacrylamide (CBMAA) on its surface to prepare zwitterionic dendrimer (G5-CBMAAn). The results showed that G5-CBMAA30 had the longest blood circulation time due to its thickest zwitterionic layer, and its residual rate after injection into mice at 2 and 12 h was as high as 47.22 % and 14.37 %, respectively. Nanodrug G5-CBMAA30-ICG was prepared by containing indocyanine green (ICG) in the cavity of G5-CBMAA30. G5-CBMAA30-ICG had better tumor targeting ability and antitumor effect than free ICG in mice after laser irradiation, and the tumor inhibition rate was 96.6 % after 14 days’ treatment. The prepared G5-CBMAA30-ICG has great potential applications in the field of antitumor by phototherapy.
Anticancer, Dendrimer, Long-circulation, Phototherapy, Zwitterionic
Guo, Xiaolei
1c18e51b-b070-40e8-b741-ce3f834ce626
Li, Shukai
192780a9-4cd4-492b-beea-9cce2cbe4f56
Tian, Jingrui
7f8bbfb3-76f9-4399-a8be-5bcbdc7e920b
Chen, Shengfu
1dd723db-42b2-4df0-be13-ae8555a4b946
Ma, Guanglong
4ba2ed72-fcf8-4116-8548-6d4774a80934
Xiao, Haiyan
d4f2d0c6-ad07-4630-871a-2b006e6e9e39
Liu, Zhiwei
2cccd24d-8826-49ea-8884-862a0bcf6e10
Wang, Longgang
fa6e2c69-1986-4161-b285-774fb453e124
Jiang, Xiaohua
58839217-38ee-45c3-b653-3b6aa7216f13
1 September 2022
Guo, Xiaolei
1c18e51b-b070-40e8-b741-ce3f834ce626
Li, Shukai
192780a9-4cd4-492b-beea-9cce2cbe4f56
Tian, Jingrui
7f8bbfb3-76f9-4399-a8be-5bcbdc7e920b
Chen, Shengfu
1dd723db-42b2-4df0-be13-ae8555a4b946
Ma, Guanglong
4ba2ed72-fcf8-4116-8548-6d4774a80934
Xiao, Haiyan
d4f2d0c6-ad07-4630-871a-2b006e6e9e39
Liu, Zhiwei
2cccd24d-8826-49ea-8884-862a0bcf6e10
Wang, Longgang
fa6e2c69-1986-4161-b285-774fb453e124
Jiang, Xiaohua
58839217-38ee-45c3-b653-3b6aa7216f13
Guo, Xiaolei, Li, Shukai, Tian, Jingrui, Chen, Shengfu, Ma, Guanglong, Xiao, Haiyan, Liu, Zhiwei, Wang, Longgang and Jiang, Xiaohua
(2022)
Long-circulation zwitterionic dendrimer nanodrugs for phototherapy of tumors.
Colloids and Surfaces B: Biointerfaces, 217, [112681].
(doi:10.1016/j.colsurfb.2022.112681).
Abstract
The development of stealth and effective antitumor nanodrugs has been drawing great attention. Herein, generation five poly(amide amine) dendrimer (G5 PAMAM) was modified by zwitterionic material carboxybetaine methacrylamide (CBMAA) on its surface to prepare zwitterionic dendrimer (G5-CBMAAn). The results showed that G5-CBMAA30 had the longest blood circulation time due to its thickest zwitterionic layer, and its residual rate after injection into mice at 2 and 12 h was as high as 47.22 % and 14.37 %, respectively. Nanodrug G5-CBMAA30-ICG was prepared by containing indocyanine green (ICG) in the cavity of G5-CBMAA30. G5-CBMAA30-ICG had better tumor targeting ability and antitumor effect than free ICG in mice after laser irradiation, and the tumor inhibition rate was 96.6 % after 14 days’ treatment. The prepared G5-CBMAA30-ICG has great potential applications in the field of antitumor by phototherapy.
Text
COLSUB-D-22-00025_R1 (1)(1)
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Accepted/In Press date: 29 June 2022
e-pub ahead of print date: 6 July 2022
Published date: 1 September 2022
Additional Information:
Funding Information:
The authors appreciate financial support from National Natural Science Foundation of China ( 21674092 and 21975216 ), National Development Project on Key Basic Research (973 Project, 2015CB655303 ), Natural Science Foundation of Hebei Province ( B2017203229 ), and China Postdoctoral Science Foundation ( 2016M601284 ).
Publisher Copyright:
© 2022 Elsevier B.V.
Keywords:
Anticancer, Dendrimer, Long-circulation, Phototherapy, Zwitterionic
Identifiers
Local EPrints ID: 477612
URI: http://eprints.soton.ac.uk/id/eprint/477612
ISSN: 0927-7765
PURE UUID: 4dd1cef3-27d9-4f7f-a6d4-fead283baceb
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Date deposited: 09 Jun 2023 16:50
Last modified: 17 Mar 2024 13:20
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Author:
Xiaolei Guo
Author:
Shukai Li
Author:
Jingrui Tian
Author:
Shengfu Chen
Author:
Guanglong Ma
Author:
Haiyan Xiao
Author:
Zhiwei Liu
Author:
Longgang Wang
Author:
Xiaohua Jiang
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