Comparison of cardiovascular mortality between MAFLD and NAFLD: a cohort study
Comparison of cardiovascular mortality between MAFLD and NAFLD: a cohort study
Background and aims: a new diagnostic criterion of metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed. However, only few studies have shown that MAFLD predicts cardiovascular disease (CVD) mortality better than non-alcoholic fatty liver disease (NAFLD). Therefore, a cohort study was conducted to assess this relationship.
Methods and results: health examination data from health care centers in South Korea were assessed after excluding participants with missing covariates and cancer history (n = 701,664). Liver ultrasonography reports, laboratory and anthropometric data were extracted. Diagnoses of NAFLD and MAFLD were performed according to standard definitions. Participants were categorized based on the presence of NAFLD and MAFLD. In addition, participants were classified into five categories: no fatty liver disease (no FLD), NAFLD-only, MAFLD-only, both FLDs, and alcoholic FLD (AFLD) and non-MAFLD. Multivariable regression modeling was performed. The median follow-up duration was 8.77 years, and 52.56% of participants were men. After stratifying the cohort into no-MAFLD and MAFLD groups, MAFLD was associated with increased CVD mortality (adjusted HR 1.14, 95% CI 1.02–1.28). When participants were divided into no-NAFLD and NAFLD groups, there was a non-significant trend towards an increase in CVD mortality in NAFLD group (adjusted HR 1.07, 95% CI 0.95–1.21). When participants were divided into five categories, MAFLD-only group showed increased CVD mortality (adjusted HR 1.35, 95% CI 1.07–1.70) while NAFLD-only group showed no significant association with CVD mortality (adjusted HR 0.67, 95% CI 0.38–1.19).
Conclusions: in conclusion, MAFLD is associated with increased CVD mortality in a relatively young Korean population.
Cardiovascular disease mortality, MAFLD, NAFLD
947-955
Yoo, Tae Kyung
ae23f9a8-d927-4c9c-bea3-123b0a687e35
Lee, Mi Yeon
23ff8407-d5b7-491a-9207-cc169d9a1236
Kim, Seong Hwan
8ad3bf3d-d739-46b7-b286-b341137935c8
Zheng, Ming-Hua
aeb6baad-e5f0-4531-8055-6f1dff3abf57
Targher, Giovanni
042a33db-48ea-4b86-8c3d-291dc872ea80
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Sung, Ki-Chul
7665e3b1-4425-44ce-a143-43764baf7afc
17 May 2023
Yoo, Tae Kyung
ae23f9a8-d927-4c9c-bea3-123b0a687e35
Lee, Mi Yeon
23ff8407-d5b7-491a-9207-cc169d9a1236
Kim, Seong Hwan
8ad3bf3d-d739-46b7-b286-b341137935c8
Zheng, Ming-Hua
aeb6baad-e5f0-4531-8055-6f1dff3abf57
Targher, Giovanni
042a33db-48ea-4b86-8c3d-291dc872ea80
Byrne, Christopher
1370b997-cead-4229-83a7-53301ed2a43c
Sung, Ki-Chul
7665e3b1-4425-44ce-a143-43764baf7afc
Yoo, Tae Kyung, Lee, Mi Yeon, Kim, Seong Hwan, Zheng, Ming-Hua, Targher, Giovanni, Byrne, Christopher and Sung, Ki-Chul
(2023)
Comparison of cardiovascular mortality between MAFLD and NAFLD: a cohort study.
Nutrition, Metabolism & Cardiovascular Diseases, 33 (5), .
(doi:10.1016/j.numecd.2023.01.013).
Abstract
Background and aims: a new diagnostic criterion of metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed. However, only few studies have shown that MAFLD predicts cardiovascular disease (CVD) mortality better than non-alcoholic fatty liver disease (NAFLD). Therefore, a cohort study was conducted to assess this relationship.
Methods and results: health examination data from health care centers in South Korea were assessed after excluding participants with missing covariates and cancer history (n = 701,664). Liver ultrasonography reports, laboratory and anthropometric data were extracted. Diagnoses of NAFLD and MAFLD were performed according to standard definitions. Participants were categorized based on the presence of NAFLD and MAFLD. In addition, participants were classified into five categories: no fatty liver disease (no FLD), NAFLD-only, MAFLD-only, both FLDs, and alcoholic FLD (AFLD) and non-MAFLD. Multivariable regression modeling was performed. The median follow-up duration was 8.77 years, and 52.56% of participants were men. After stratifying the cohort into no-MAFLD and MAFLD groups, MAFLD was associated with increased CVD mortality (adjusted HR 1.14, 95% CI 1.02–1.28). When participants were divided into no-NAFLD and NAFLD groups, there was a non-significant trend towards an increase in CVD mortality in NAFLD group (adjusted HR 1.07, 95% CI 0.95–1.21). When participants were divided into five categories, MAFLD-only group showed increased CVD mortality (adjusted HR 1.35, 95% CI 1.07–1.70) while NAFLD-only group showed no significant association with CVD mortality (adjusted HR 0.67, 95% CI 0.38–1.19).
Conclusions: in conclusion, MAFLD is associated with increased CVD mortality in a relatively young Korean population.
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Accepted/In Press date: 16 January 2023
e-pub ahead of print date: 25 January 2023
Published date: 17 May 2023
Additional Information:
Funding Information:
None.
Keywords:
Cardiovascular disease mortality, MAFLD, NAFLD
Identifiers
Local EPrints ID: 477633
URI: http://eprints.soton.ac.uk/id/eprint/477633
ISSN: 0939-4753
PURE UUID: 3baa51f7-9a26-436e-9d2a-13e1818b6a3f
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Date deposited: 09 Jun 2023 17:02
Last modified: 17 Mar 2024 07:43
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Author:
Tae Kyung Yoo
Author:
Mi Yeon Lee
Author:
Seong Hwan Kim
Author:
Ming-Hua Zheng
Author:
Giovanni Targher
Author:
Ki-Chul Sung
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