Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimmers as HIV-1 vaccine candidates

Accepted/In Press date: 29 March 2023

e-pub ahead of print date: 8 April 2023

Published date: 8 April 2023

Additional Information: Funding Information: Y.-N.Z. acknowledges support from the Natural Sciences and Engineering Research Council of Canada (NSERC) for the postdoctoral fellowship. We thank M. Ganguly, K. Duffin, and G. Ossetchkine at The Centre for Phenogenomics for their technical support in immunohistology. We thank K. Vanderpool, T. Fassel, and S. Henderson of the Core Microscopy Facility at The Scripps Research Institute for their expert assistance in the TEM analysis. We thank A. Saluk, B. Seegers, and B. Monteverde of the Flow Cytometry Core Facility at The Scripps Research Institute for their technical support in flow cytometry. We thank P. Berman and D. Burton for helpful discussions and M. Arends, S. Auclair, and V. Tong for proofreading the manuscript. This work was supported by the International AIDS Vaccine Initiative (IAVI) through grant INV-008352/OPP1153692 (M.C.) and the IAVI Neutralizing Antibody Center through the Collaboration for AIDS Vaccine Discovery grant (INV-034657) (I.A.W., A.B.W.), and INV-008352/OPP1153692 (M.C.) funded by the Bill and Melinda Gates Foundation; Scripps Consortium for HIV/AIDS Vaccine Development (CHAVD 1UM1 AI144462) (M.C., A.B.W. and I.A.W.); HIV Vaccine Research and Design (HIVRAD) program (P01 AI124337) (J.Z.); NIH grants R01 AI129698 (J.Z.) and R01 AI140844 (J.Z., I.A.W.); Southwest National Primate Research Center through grants P51 OD011133 and U42OD010442 and Tulane National Primate Research Center through grant P51 OD011104 from the Office of Research Infrastructure Programs, NIH (R.L., C.C.); Ufovax/SFP-2018-0416 (J.Z.) and Ufovax/SFP-2018-1013 (J.Z.).

Keywords: HIV antibodies, HIV infections, HIV-1, animals, antibodies, neutralizing, env gene products, human immunodeficiency virus, mice, polysaccharides/metabolism, rabbits, vaccines/metabolism

Local EPrints ID: 477641

URI: http://eprints.soton.ac.uk/id/eprint/477641

DOI: doi:10.1038/s41467-023-37742-z

ISSN: 2041-1723

PURE UUID: a2998e28-bc09-4794-a728-5d0c5d3c5105

ORCID for Joel D. Allen: orcid.org/0000-0003-2547-968X

ORCID for Max Crispin: orcid.org/0000-0002-1072-2694

Date deposited: 12 Jun 2023 16:36

Last modified: 17 Mar 2024 04:09