A natural virucidal and microbicidal spray based on polyphenol-iron sols
A natural virucidal and microbicidal spray based on polyphenol-iron sols
Numerous disinfection methods have been developed to reduce the transmission of infectious diseases that threaten human health. However, it still remains elusively challenging to develop eco-friendly and cost-effective methods that deactivate a wide range of pathogens, from viruses to bacteria and fungi, without doing any harm to humans or the environment. Herein we report a natural spraying protocol, based on a water-dispersible supramolecular sol of nature-derived tannic acid (TA) and Fe3+, which is easy-to-use and low-cost. Our formulation effectively deactivates viruses (influenza A viruses, SARS-CoV-2, and human rhinovirus) as well as suppressing the growth and spread of pathogenic bacteria (Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, and Acinetobacter baumannii) and fungi (Pleurotus ostreatus and Trichophyton rubrum). Its versatile applicability in a real-life setting is also demonstrated against microorganisms present on the surfaces of common household items (e.g., air filter membranes, disposable face masks, kitchen sinks, mobile phones, refrigerators, and toilet seats).
metal-phenolic sol, microbicidal, polyphenols, spraying, virucidal, Anti-Infective Agents/pharmacology, Humans, Escherichia coli, Viruses, Polyphenols/pharmacology, Fungi, SARS-CoV-2, Disinfection/methods, COVID-19/prevention & control, Bacteria
1981–1991
Han, Sang Yeong
b21e1aec-75a8-4e20-91cd-4e6b63d2eb5c
Yun, Gyeongwon
cb83add4-4990-4da0-b582-34d9323aa378
Cha, Hyeon Min
5047b5ef-d4a5-4f93-853c-f4864542401d
Lee, Myoung Kyu
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Lee, Hojae
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Kang, Eunhye K.
c240e611-6b5b-48e0-9579-ea542b7e0154
Hong, Seok Pyo
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Teahan, Kirsty A.
be1b5297-0209-40c5-b166-f9806fb5e3af
Park, Minjeong
6562e007-fc23-4620-bf6f-93385c8cb22c
Hwang, Hansol
c6c2f586-3251-4c42-822b-880088bd6356
Lee, Seung Seo
ee34fa26-5fb6-48c8-80c2-1f13ec4ccceb
Kim, Meehyein
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Choi, Insung S.
776770c5-7fe0-452b-8b38-ca46c5060174
15 May 2023
Han, Sang Yeong
b21e1aec-75a8-4e20-91cd-4e6b63d2eb5c
Yun, Gyeongwon
cb83add4-4990-4da0-b582-34d9323aa378
Cha, Hyeon Min
5047b5ef-d4a5-4f93-853c-f4864542401d
Lee, Myoung Kyu
1929a3d9-ec1a-4abd-abff-48a0b133c689
Lee, Hojae
baad9a46-540c-4b0b-8a68-5dd5ffd739ec
Kang, Eunhye K.
c240e611-6b5b-48e0-9579-ea542b7e0154
Hong, Seok Pyo
2d453baf-5c16-443c-b1ef-b64bfc50da6b
Teahan, Kirsty A.
be1b5297-0209-40c5-b166-f9806fb5e3af
Park, Minjeong
6562e007-fc23-4620-bf6f-93385c8cb22c
Hwang, Hansol
c6c2f586-3251-4c42-822b-880088bd6356
Lee, Seung Seo
ee34fa26-5fb6-48c8-80c2-1f13ec4ccceb
Kim, Meehyein
3aab2945-dafa-4b5d-9024-c2bf984f2392
Choi, Insung S.
776770c5-7fe0-452b-8b38-ca46c5060174
Han, Sang Yeong, Yun, Gyeongwon, Cha, Hyeon Min, Lee, Myoung Kyu, Lee, Hojae, Kang, Eunhye K., Hong, Seok Pyo, Teahan, Kirsty A., Park, Minjeong, Hwang, Hansol, Lee, Seung Seo, Kim, Meehyein and Choi, Insung S.
(2023)
A natural virucidal and microbicidal spray based on polyphenol-iron sols.
ACS Applied Bio Materials, 6 (5), .
(doi:10.1021/acsabm.3c00195).
Abstract
Numerous disinfection methods have been developed to reduce the transmission of infectious diseases that threaten human health. However, it still remains elusively challenging to develop eco-friendly and cost-effective methods that deactivate a wide range of pathogens, from viruses to bacteria and fungi, without doing any harm to humans or the environment. Herein we report a natural spraying protocol, based on a water-dispersible supramolecular sol of nature-derived tannic acid (TA) and Fe3+, which is easy-to-use and low-cost. Our formulation effectively deactivates viruses (influenza A viruses, SARS-CoV-2, and human rhinovirus) as well as suppressing the growth and spread of pathogenic bacteria (Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, and Acinetobacter baumannii) and fungi (Pleurotus ostreatus and Trichophyton rubrum). Its versatile applicability in a real-life setting is also demonstrated against microorganisms present on the surfaces of common household items (e.g., air filter membranes, disposable face masks, kitchen sinks, mobile phones, refrigerators, and toilet seats).
Text
Choi et al_MS_revised_FV
- Accepted Manuscript
More information
Accepted/In Press date: 9 April 2023
e-pub ahead of print date: 21 April 2023
Published date: 15 May 2023
Additional Information:
Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (MSIT) (2021R1A3A3002527 for I.S.C. and 2018M3A9H4089601 for M.K.). K.A.T. is supported by the Institute for Life Sciences studentship (U. Southampton). Part of the work was supported by Hansol RootOne. The SARS-CoV-2 resource (NCCP No., 43328) was provided by the National Culture Collection for Pathogens, Republic of Korea.
Keywords:
metal-phenolic sol, microbicidal, polyphenols, spraying, virucidal, Anti-Infective Agents/pharmacology, Humans, Escherichia coli, Viruses, Polyphenols/pharmacology, Fungi, SARS-CoV-2, Disinfection/methods, COVID-19/prevention & control, Bacteria
Identifiers
Local EPrints ID: 477727
URI: http://eprints.soton.ac.uk/id/eprint/477727
ISSN: 2576-6422
PURE UUID: 2b05a590-5be4-431b-9ab6-8325161b9338
Catalogue record
Date deposited: 13 Jun 2023 17:23
Last modified: 06 Jun 2024 04:01
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Contributors
Author:
Sang Yeong Han
Author:
Gyeongwon Yun
Author:
Hyeon Min Cha
Author:
Myoung Kyu Lee
Author:
Hojae Lee
Author:
Eunhye K. Kang
Author:
Seok Pyo Hong
Author:
Kirsty A. Teahan
Author:
Minjeong Park
Author:
Hansol Hwang
Author:
Meehyein Kim
Author:
Insung S. Choi
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