A scoping review: urinary markers of metabolic maturation in infants with CHD and the relationship to growth
A scoping review: urinary markers of metabolic maturation in infants with CHD and the relationship to growth
Background: growth failure in infants born with CHD is a persistent problem, even in those provided with adequate nutrition.
Objective: to summarise the published data describing the change in urinary metabolites during metabolic maturation in infants with CHD and identify pathways amenable to therapeutic intervention
Design: scoping review.
Eligibility criteria: studies using qualitative or quantitative methods to describe urinary metabolites pre- and post-cardiac surgery and the relationship with growth in infants with CHD.
Sources of evidence: NICE Healthcare Databases website was used as a tool for multiple searches.
Results: 347 records were identified, of which 37 were duplicates. Following the removal of duplicate records, 310 record abstracts and titles were screened for inclusion. The full texts of eight articles were reviewed for eligibility, of which only two related to infants with CHD. The studies included in the scoping review described urinary metabolites in 42 infants. A content analysis identified two overarching themes of metabolic variation predictive of neurodevelopmental abnormalities associated with anaerobic metabolism and metabolic signature associated with the impact on gut microbiota, inflammation, energy, and lipid digestion.
Conclusion: the results of this scoping review suggest that there are considerable gaps in our knowledge relating to metabolic maturation of infants with CHD, especially with respect to growth. Surgery is a key early life feature for CHD infants and has an impact on the developing biochemical phenotype with implications for metabolic pathways involved in immunomodulation, energy, gut microbial, and lipid metabolism. These early life fingerprints may predict those individuals at risk for neurodevelopmental abnormalities.
1879-1888
Marino, Luise V.
c479400f-9424-4879-9ca6-d81e6351de26
Paulson, Simone
47d52e9c-4378-4ccb-83c7-5460047a5eca
Ashton, James J.
1c0bfa29-794c-4fd5-93e0-6769e6037d72
Weeks, Charlotte
5d72919b-617c-4a93-9f31-b2d7d404b99d
Young, Aneurin
457b536d-6015-4855-8e4c-0a665a9a2bb1
Pappachan, John V.P.
8e1bd6bd-1cb9-4dd9-a9af-b9eed5459148
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Beattie, R. Mark
9a66af0b-f81c-485c-b01d-519403f0038a
Johnson, Mark J.
ce07b5dd-b12b-47df-a5df-cd3b9447c9ed
Marino, Luise V.
c479400f-9424-4879-9ca6-d81e6351de26
Paulson, Simone
47d52e9c-4378-4ccb-83c7-5460047a5eca
Ashton, James J.
1c0bfa29-794c-4fd5-93e0-6769e6037d72
Weeks, Charlotte
5d72919b-617c-4a93-9f31-b2d7d404b99d
Young, Aneurin
457b536d-6015-4855-8e4c-0a665a9a2bb1
Pappachan, John V.P.
8e1bd6bd-1cb9-4dd9-a9af-b9eed5459148
Swann, Jonathan
7c11a66b-f4b8-4dbf-aa17-ad8b0561b85c
Beattie, R. Mark
9a66af0b-f81c-485c-b01d-519403f0038a
Johnson, Mark J.
ce07b5dd-b12b-47df-a5df-cd3b9447c9ed
Marino, Luise V., Paulson, Simone, Ashton, James J., Weeks, Charlotte, Young, Aneurin, Pappachan, John V.P., Swann, Jonathan, Beattie, R. Mark and Johnson, Mark J.
(2022)
A scoping review: urinary markers of metabolic maturation in infants with CHD and the relationship to growth.
Cardiology in the Young, 33 (10), .
(doi:10.1017/s1047951122003262).
Abstract
Background: growth failure in infants born with CHD is a persistent problem, even in those provided with adequate nutrition.
Objective: to summarise the published data describing the change in urinary metabolites during metabolic maturation in infants with CHD and identify pathways amenable to therapeutic intervention
Design: scoping review.
Eligibility criteria: studies using qualitative or quantitative methods to describe urinary metabolites pre- and post-cardiac surgery and the relationship with growth in infants with CHD.
Sources of evidence: NICE Healthcare Databases website was used as a tool for multiple searches.
Results: 347 records were identified, of which 37 were duplicates. Following the removal of duplicate records, 310 record abstracts and titles were screened for inclusion. The full texts of eight articles were reviewed for eligibility, of which only two related to infants with CHD. The studies included in the scoping review described urinary metabolites in 42 infants. A content analysis identified two overarching themes of metabolic variation predictive of neurodevelopmental abnormalities associated with anaerobic metabolism and metabolic signature associated with the impact on gut microbiota, inflammation, energy, and lipid digestion.
Conclusion: the results of this scoping review suggest that there are considerable gaps in our knowledge relating to metabolic maturation of infants with CHD, especially with respect to growth. Surgery is a key early life feature for CHD infants and has an impact on the developing biochemical phenotype with implications for metabolic pathways involved in immunomodulation, energy, gut microbial, and lipid metabolism. These early life fingerprints may predict those individuals at risk for neurodevelopmental abnormalities.
Text
a-scoping-review-urinary-markers-of-metabolic-maturation-in-infants-with-chd-and-the-relationship-to-growth
- Version of Record
More information
e-pub ahead of print date: 3 November 2022
Identifiers
Local EPrints ID: 477804
URI: http://eprints.soton.ac.uk/id/eprint/477804
ISSN: 1047-9511
PURE UUID: 973927f5-0b1f-4ddc-9335-315a700fd4db
Catalogue record
Date deposited: 14 Jun 2023 16:52
Last modified: 17 Mar 2024 04:23
Export record
Altmetrics
Contributors
Author:
Luise V. Marino
Author:
Simone Paulson
Author:
James J. Ashton
Author:
Charlotte Weeks
Author:
Aneurin Young
Author:
John V.P. Pappachan
Author:
R. Mark Beattie
Author:
Mark J. Johnson
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics