Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.
691–697
Epple, Sven
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El-Sagheer, Afaf
05b8295a-64ad-4fdf-ad57-c34934a46c04
Brown, Tom
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1 November 2021
Epple, Sven
0a1f70bd-7366-48a9-a1ee-7d747ff652ab
El-Sagheer, Afaf
05b8295a-64ad-4fdf-ad57-c34934a46c04
Brown, Tom
a64aae36-bb30-42df-88a2-11be394e8c89
Epple, Sven, El-Sagheer, Afaf and Brown, Tom
(2021)
Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology.
Emerging Topics in Life Sciences, 5 (5), .
(doi:10.1042/ETLS20210169).
Abstract
The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.
Text
etls-2021-0169c
- Version of Record
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Accepted/In Press date: 14 July 2021
e-pub ahead of print date: 23 July 2021
Published date: 1 November 2021
Identifiers
Local EPrints ID: 477928
URI: http://eprints.soton.ac.uk/id/eprint/477928
ISSN: 2397-8562
PURE UUID: a629cd80-c36b-4242-bcb7-595f1cf9a03c
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Date deposited: 16 Jun 2023 16:42
Last modified: 17 Mar 2024 03:04
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Author:
Sven Epple
Author:
Afaf El-Sagheer
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