Sedation in the Intensive Care Unit
Sedation in the Intensive Care Unit
Purpose of Review
This narrative review illustrates literature over the last 5 years relating to sedation delivery to mechanically ventilated adult patients in intensive care units.
Recent Findings
There has been an increase in dexmedetomidine-related publications but although systematic reviews suggest dexmedetomidine reduces delirium, agitation, and length of stay, clinical trials have not supported these findings. It is likely to be useful for the managing patients with persisting agitation. Guidelines continue to recommend lightly sedating patients but considerable variation remains in clinical practice and in research trials. Protocols with no sedative infusions and morphine boluses as needed are feasible and safe, while educational interventions can decrease sedation-related adverse events.
Summary
Research trials have mainly focused on individual drugs rather than practice. Given evidence is slow to translate into practice; work is needed to understand and respond to the concerns of clinicians regarding deep sedation and agitation.
Page, V
b0895d93-8ca6-4d44-b9ba-aed0ddbc1070
McKenzie, C
ec344dee-5777-49c5-970e-6326e82c9f8c
24 April 2021
Page, V
b0895d93-8ca6-4d44-b9ba-aed0ddbc1070
McKenzie, C
ec344dee-5777-49c5-970e-6326e82c9f8c
Abstract
Purpose of Review
This narrative review illustrates literature over the last 5 years relating to sedation delivery to mechanically ventilated adult patients in intensive care units.
Recent Findings
There has been an increase in dexmedetomidine-related publications but although systematic reviews suggest dexmedetomidine reduces delirium, agitation, and length of stay, clinical trials have not supported these findings. It is likely to be useful for the managing patients with persisting agitation. Guidelines continue to recommend lightly sedating patients but considerable variation remains in clinical practice and in research trials. Protocols with no sedative infusions and morphine boluses as needed are feasible and safe, while educational interventions can decrease sedation-related adverse events.
Summary
Research trials have mainly focused on individual drugs rather than practice. Given evidence is slow to translate into practice; work is needed to understand and respond to the concerns of clinicians regarding deep sedation and agitation.
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Accepted/In Press date: 23 March 2021
Published date: 24 April 2021
Identifiers
Local EPrints ID: 477948
URI: http://eprints.soton.ac.uk/id/eprint/477948
ISSN: 1523-3855
PURE UUID: cb96d395-577c-4b3b-ab60-eeadfe7d03c4
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Date deposited: 16 Jun 2023 16:52
Last modified: 17 Mar 2024 04:23
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V Page
Author:
C McKenzie
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