Feasibility of a cardiopulmonary exercise test (CPET) derived high-intensity interval training programme (HIIT) in idiopathic pulmonary fibrosis (IPF)
Feasibility of a cardiopulmonary exercise test (CPET) derived high-intensity interval training programme (HIIT) in idiopathic pulmonary fibrosis (IPF)
Introduction: exercise training is recommended for IPF patients but the optimum program and the mechanisms underlying improvements in exercise capacity are unknown. We tested feasibility of a HIIT in IPF.
Methods: a single-centre study of IPF patients. An 8-week twice-weekly cycle-ergometer based HIIT was personalised using participants volume of oxygen consumption at anaerobic threshold (VO2AT) and peak (VO2peak) assessed by incremental CPET. Primary outcome was endurance time on constant load test at 75% VO2peak. Ethical approval obtained (REC 17/SC/0342).
Results: interim analysis of 11 patients. Baseline demographics as follows; males 82% with mean (SD) age 73.5years (6.8), FVC% 76.5 (13.4) and DLCO% 50.1 (15.8). Participants had significantly impaired exercise capacity at baseline with mean (SD) VO2peak of 12.3ml/kg/min (3.3) and VO2AT 8.3ml/kg/min (1.3).
Participants had good adherence to HITT with mean of 15/16 sessions attended with no serious adverse events. HITT led to clinically meaningful improvement in mean endurance time [pre 8.3min vs post 16.8min difference 8.5min (95%CI 4.2-12.8) p<0.01] and 6min walk [pre 374m vs post 409m difference 35m (95%CI 0.6-69.4) p<0.05]. Significant increase was also observed in mean peak minute ventilation (peakVE) [pre 60.2L/min vs post 69.3L/min p=0.02]. However no change was observed in either VO2peak or VO2AT following HITT.
Conclusion: a CPET derived HIIT was feasible in this cohort of IPF patients and led to significant improvement in endurance time and 6min walk. Increased peakVE following HITT suggests improved ventilatory mechanics may in part account for increased exercise test performance.
Wallis, Tim
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Pontoppidan, Katarina
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Gove, Kerry
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Hill, David
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Cullinane, James
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Thompson, Fiona
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Brereton, Christopher
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Freeman, Anna
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Fletcher, Sophie
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Grocott, Michael
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Jones, Mark
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Jack, Sandy
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7 September 2020
Wallis, Tim
edff1a32-dd2f-418a-a724-fd0ab2977081
Pontoppidan, Katarina
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Gove, Kerry
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Hill, David
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Cullinane, James
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Thompson, Fiona
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Brereton, Christopher
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Freeman, Anna
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Fletcher, Sophie
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Grocott, Michael
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Jones, Mark
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Jack, Sandy
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Wallis, Tim, Pontoppidan, Katarina, Gove, Kerry, Hill, David, Cullinane, James, Thompson, Fiona, Brereton, Christopher, Freeman, Anna, Fletcher, Sophie, Grocott, Michael, Jones, Mark and Jack, Sandy
(2020)
Feasibility of a cardiopulmonary exercise test (CPET) derived high-intensity interval training programme (HIIT) in idiopathic pulmonary fibrosis (IPF).
European Respiratory Journal, 56 (64), [775].
(doi:10.1183/13993003.congress-2020.775).
Record type:
Meeting abstract
Abstract
Introduction: exercise training is recommended for IPF patients but the optimum program and the mechanisms underlying improvements in exercise capacity are unknown. We tested feasibility of a HIIT in IPF.
Methods: a single-centre study of IPF patients. An 8-week twice-weekly cycle-ergometer based HIIT was personalised using participants volume of oxygen consumption at anaerobic threshold (VO2AT) and peak (VO2peak) assessed by incremental CPET. Primary outcome was endurance time on constant load test at 75% VO2peak. Ethical approval obtained (REC 17/SC/0342).
Results: interim analysis of 11 patients. Baseline demographics as follows; males 82% with mean (SD) age 73.5years (6.8), FVC% 76.5 (13.4) and DLCO% 50.1 (15.8). Participants had significantly impaired exercise capacity at baseline with mean (SD) VO2peak of 12.3ml/kg/min (3.3) and VO2AT 8.3ml/kg/min (1.3).
Participants had good adherence to HITT with mean of 15/16 sessions attended with no serious adverse events. HITT led to clinically meaningful improvement in mean endurance time [pre 8.3min vs post 16.8min difference 8.5min (95%CI 4.2-12.8) p<0.01] and 6min walk [pre 374m vs post 409m difference 35m (95%CI 0.6-69.4) p<0.05]. Significant increase was also observed in mean peak minute ventilation (peakVE) [pre 60.2L/min vs post 69.3L/min p=0.02]. However no change was observed in either VO2peak or VO2AT following HITT.
Conclusion: a CPET derived HIIT was feasible in this cohort of IPF patients and led to significant improvement in endurance time and 6min walk. Increased peakVE following HITT suggests improved ventilatory mechanics may in part account for increased exercise test performance.
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Published date: 7 September 2020
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This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
Venue - Dates:
European Respiratory Society International Congress 2020, Virtual, Vienna, Austria, 2020-09-06 - 2020-09-09
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Local EPrints ID: 477967
URI: http://eprints.soton.ac.uk/id/eprint/477967
ISSN: 0903-1936
PURE UUID: 3da47e3d-0431-4635-9e2e-c8215e06f1af
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Date deposited: 19 Jun 2023 16:32
Last modified: 17 Mar 2024 04:06
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Author:
Tim Wallis
Author:
Katarina Pontoppidan
Author:
Kerry Gove
Author:
David Hill
Author:
James Cullinane
Author:
Fiona Thompson
Author:
Christopher Brereton
Author:
Anna Freeman
Author:
Sophie Fletcher
Author:
Mark Jones
Author:
Sandy Jack
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