Copy number variants are ovarian cancer risk alleles at known and novel risk loci

Accepted/In Press date: 18 August 2022

Published date: 10 October 2022

Additional Information: Funding: This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health (5T32GM118288-03); the CSMC Precision Health Initiative; and the Tell Every Amazing Lady About Ovarian Cancer Louisa M. McGregor Ovarian Cancer Foundation. Supported in part by the Ovarian Cancer Research Fund thanks to donations by the family and friends of Kathryn Sladek Smith (PPD/RPCI.07); the US National Cancer Institute GAME-ON Post-GWAS Initiative (U19-CA148112); the Wellcome Trust (076113; the National Cancer Institute and National Human Genome Research Institute (dbGap accession number phs000178.v8.p7); the U.S. National Institutes of Health (CA1X01HG007491-01 (CIA), U19-CA148112 (TAS), R01-CA149429 (CMP) and R01-CA058598 (MTG); Canadian Institutes of Health Research (MOP-86727 (LEK); the Ovarian Cancer Research Fund (AB); a European Commission’s Seventh Framework Programme grant (agreement number 223175 - HEALTH-F2-2009-223175); the U.S. Army Medical Research and Materiel Command (DAMD17-01-1-0729); National Health & Medical Research Council of Australia (199600, 400413 and 400281); Cancer Councils of New South Wales, Victoria, Queensland, South Australia and Tasmania and Cancer Foundation of Western Australia (Multi-State Applications 191, 211 and 182); Ovarian Cancer Australia and the Peter MacCallum Foundation; ELAN Funds of the University of Erlangen-Nuremberg; National Kankerplan; Breast Cancer Now, Institute of Cancer Research; the National Institutes of Health (NIH)/National Center for Advancing Translational Sciences (NCATS) (ULTR000445 - the 1S10RR025141-01 instrumentation award and Vanderbilt CTSA grant); the European Commission (DG-SANCO); the International Agency for Research on Cancer; Danish Cancer Society (Denmark) (EMC 2014-6699); Ligue Contre le Cancer, Institut Gustave Roussy, Mutuelle Générale de l’Education Nationale; Institut National de la Santé et de la Recherche Médicale (INSERM) (France); German Cancer Aid; German Cancer Research Center (DKFZ); Federal Ministry of Education and Research (BMBF) (Germany); the Hellenic Health Foundation (Greece); Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy and National Research Council (Italy); Dutch Ministry of Public Health, Welfare and Sports (VWS); Netherlands Cancer Registry (NKR); LK Research Funds; Dutch Prevention Funds; Dutch ZON (Zorg Onderzoek Nederland); World Cancer Research Fund (WCRF); Statistics Netherlands (the Netherlands); ERC-2009-AdG 232997 and Nordforsk, Nordic Centre of Excellence programme on Food, Nutrition and Health (Norway); Health Research Fund (FIS), PI13/00061 to Granada, PI13/01162 to EPIC-Murcia; Regional Governments of Andalucía, Asturias, Basque Country, Murcia and Navarra, ISCIII RETIC (RD06/0020) (Spain); Swedish Cancer Society, Swedish Research Council and County Councils of Skåne and Västerbotten (Sweden); Cancer Research UK (14136 to EPIC-Norfolk; C570/A16491 and C8221/A19170 to EPIC-Oxford), Medical Research Council (1000143 to EPIC-Norfolk, MR/M012190/1 to EPIC-Oxford) (United Kingdom); German Federal Ministry of Education and Research, Programme of Clinical Biomedical Research (01 GB 9401) and the German Cancer Research Center (DKFZ); U.S. National Institutes of Health (R01-CA58598, N01-CN-55424 and N01-PC-67001); intramural funding; Rudolf-Bartling Foundation; Helsinki University Hospital Research Fund; University of Pittsburgh School of Medicine Dean’s Faculty Advancement Award (F. Modugno); Department of Defense (DAMD17-02-1-0669); NCI (K07-CA080668, R01-CA95023, P50-CA159981 MO1-RR000056 R01-CA126841); intramural funding from the Rudolf-Bartling Foundation; ERC-2011-AdG 294576-risk factors cancer, Swedish Cancer Society, Swedish Research Council, Beta Kamprad Foundation; the National Cancer Institute (R01- CA61107), the Danish Cancer Society, Copenhagen, Denmark (94 222 52); the Mermaid I project; National Institutes of Health (R01-CA122443, P30-CA15083, P50-CA136393); Mayo Foundation; Minnesota Ovarian Cancer Alliance; Fred C. and Katherine B. Andersen Foundation; VicHealth and Cancer Council Victoria, Cancer Council Victoria, National Health and Medical Research Council of Australia (NHMRC) (209057, 251533, 396414, and 504715); DOD Ovarian Cancer Research Program (W81XWH-07-0449); Moffitt Cancer Center; Merck Pharmaceuticals; the state of Florida; Hillsborough County; the city of Tampa; National Institutes of Health (R01-CA76016); the Department of Defense (DAMD17-02-1-0666); National Institutes of Health (R01-CA54419 and P50-CA105009); Department of Defense (W81XWH-10-1-02802. UM1 CA186107, P01 CA87969, R01 CA49449, R01-CA67262, UM1 CA176726); Radboud University Medical Centre; Canadian Institutes of Health Research grant (MOP-86727); National Institutes of Health/National Cancer Institute 1 (R01CA160669-01A1); Intramural Research Program of the National Cancer Institute; Pomeranian Medical University; Cancer Research UK (C490/A10119 C490/A10124); UK National Institute for Health Research Biomedical Research Centres at the University of Cambridge; Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Z01-ES044005 and Z01-ES049033); The Swedish Cancer Foundation and the Swedish Research Council (VR 2017-00644); National Institutes of Health (R01-CA106414-A2); American Cancer Society (CRTG-00-196-01-CCE); Department of Defense (DAMD17-98-1-8659); Celma Mastry Ovarian Cancer Foundation; National Institutes of Health (R01-CA058860); the Lon V Smith Foundation (LVS-39420); The Eve Appeal (The Oak Foundation); National Institute for Health Research University College London Hospitals Biomedical Research Centre and MRC core funding (MR_UU_12023); P01CA17054, P30CA14089, R01CA61132, N01PC67010, R03CA113148, R03CA115195, N01CN025403, and California Cancer Research Program (00-01389 V-20170, 2II0200); National Science Centre (N N301 5645 40); The Maria Sklodowska-Curie Memorial Cancer Centre; and the Institute of Oncology, Warsaw, Poland. The Nurses’ Health Study (NHS) was supported by the National Institutes of Health (UM1 CA186107, P01 CA87969, R01 CA49449) and the NHS II was supported by the National Institutes of Health (U01 CA176726, R01 CA67262). Joe Dennis is supported by the CanRisk Cancer Research UK programme grant: PPRPGM-Nov20\100002 and by the Confluence project which is funded with intramural funds from the National Cancer Institute Intramural Research Programme, National Institutes of Health.

Local EPrints ID: 478022

URI: http://eprints.soton.ac.uk/id/eprint/478022

DOI: doi:10.1093/jnci/djac160

ISSN: 0027-8874

PURE UUID: acfba11b-bea0-4b01-a09f-ca1b0432f0af

ORCID for Diana M. Eccles: orcid.org/0000-0002-9935-3169

Date deposited: 19 Jun 2023 17:02

Last modified: 17 Mar 2024 02:36