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Aromatic C-H amination: a radical approach for adding new functions into biology-and materials-oriented aromatics

Aromatic C-H amination: a radical approach for adding new functions into biology-and materials-oriented aromatics
Aromatic C-H amination: a radical approach for adding new functions into biology-and materials-oriented aromatics

C-H amination is the most powerful method to directly add nitrogen functionalities into a variety of arenes including biology- and materials-oriented molecules. Recent developments in aromatic C-H amination chemistry have enabled the conversion of unactivated arenes into a range of arylamine derivatives without using directing groups or excess amounts of arenes. The key for such successful transformations is the catalytic generation of nitrogen or arene radical intermediates. In this perspective, we discuss recent developments in the radical C-H amination of aromatic molecules. We believe the resulting arylamines, which are hitherto difficult to access, will exhibit unexplored functions for biological and materials application.

1477-0520
6071-6075
Murakami, Kei
d7cf6fde-2ead-4855-b524-80c84e19e266
Perry, Gregory J.P.
766e7fc8-abf3-4d1e-9949-c1b3439a2185
Itami, Kenichiro
9b72935e-9ec7-4f27-802e-22d649c0d7e7
Murakami, Kei
d7cf6fde-2ead-4855-b524-80c84e19e266
Perry, Gregory J.P.
766e7fc8-abf3-4d1e-9949-c1b3439a2185
Itami, Kenichiro
9b72935e-9ec7-4f27-802e-22d649c0d7e7

Murakami, Kei, Perry, Gregory J.P. and Itami, Kenichiro (2017) Aromatic C-H amination: a radical approach for adding new functions into biology-and materials-oriented aromatics. Organic and Biomolecular Chemistry, 15 (29), 6071-6075. (doi:10.1039/c7ob00985b).

Record type: Review

Abstract

C-H amination is the most powerful method to directly add nitrogen functionalities into a variety of arenes including biology- and materials-oriented molecules. Recent developments in aromatic C-H amination chemistry have enabled the conversion of unactivated arenes into a range of arylamine derivatives without using directing groups or excess amounts of arenes. The key for such successful transformations is the catalytic generation of nitrogen or arene radical intermediates. In this perspective, we discuss recent developments in the radical C-H amination of aromatic molecules. We believe the resulting arylamines, which are hitherto difficult to access, will exhibit unexplored functions for biological and materials application.

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More information

Accepted/In Press date: 26 June 2017
e-pub ahead of print date: 26 June 2017

Identifiers

Local EPrints ID: 478073
URI: http://eprints.soton.ac.uk/id/eprint/478073
ISSN: 1477-0520
PURE UUID: 8e6f8058-443c-425f-ba2b-5c1d78f946a9
ORCID for Gregory J.P. Perry: ORCID iD orcid.org/0000-0001-8173-3369

Catalogue record

Date deposited: 21 Jun 2023 16:53
Last modified: 17 Mar 2024 04:19

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Contributors

Author: Kei Murakami
Author: Gregory J.P. Perry ORCID iD
Author: Kenichiro Itami

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