Aromatic C-H amination: a radical approach for adding new functions into biology-and materials-oriented aromatics
Aromatic C-H amination: a radical approach for adding new functions into biology-and materials-oriented aromatics
C-H amination is the most powerful method to directly add nitrogen functionalities into a variety of arenes including biology- and materials-oriented molecules. Recent developments in aromatic C-H amination chemistry have enabled the conversion of unactivated arenes into a range of arylamine derivatives without using directing groups or excess amounts of arenes. The key for such successful transformations is the catalytic generation of nitrogen or arene radical intermediates. In this perspective, we discuss recent developments in the radical C-H amination of aromatic molecules. We believe the resulting arylamines, which are hitherto difficult to access, will exhibit unexplored functions for biological and materials application.
6071-6075
Murakami, Kei
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Perry, Gregory J.P.
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Itami, Kenichiro
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Murakami, Kei
d7cf6fde-2ead-4855-b524-80c84e19e266
Perry, Gregory J.P.
766e7fc8-abf3-4d1e-9949-c1b3439a2185
Itami, Kenichiro
9b72935e-9ec7-4f27-802e-22d649c0d7e7
Murakami, Kei, Perry, Gregory J.P. and Itami, Kenichiro
(2017)
Aromatic C-H amination: a radical approach for adding new functions into biology-and materials-oriented aromatics.
Organic and Biomolecular Chemistry, 15 (29), .
(doi:10.1039/c7ob00985b).
Abstract
C-H amination is the most powerful method to directly add nitrogen functionalities into a variety of arenes including biology- and materials-oriented molecules. Recent developments in aromatic C-H amination chemistry have enabled the conversion of unactivated arenes into a range of arylamine derivatives without using directing groups or excess amounts of arenes. The key for such successful transformations is the catalytic generation of nitrogen or arene radical intermediates. In this perspective, we discuss recent developments in the radical C-H amination of aromatic molecules. We believe the resulting arylamines, which are hitherto difficult to access, will exhibit unexplored functions for biological and materials application.
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Accepted/In Press date: 26 June 2017
e-pub ahead of print date: 26 June 2017
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Local EPrints ID: 478073
URI: http://eprints.soton.ac.uk/id/eprint/478073
ISSN: 1477-0520
PURE UUID: 8e6f8058-443c-425f-ba2b-5c1d78f946a9
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Date deposited: 21 Jun 2023 16:53
Last modified: 17 Mar 2024 04:19
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Author:
Kei Murakami
Author:
Gregory J.P. Perry
Author:
Kenichiro Itami
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