Nitrofurantoin immune-mediated drug-induced liver injury: a serious complication of a commonly prescribed medication
Nitrofurantoin immune-mediated drug-induced liver injury: a serious complication of a commonly prescribed medication
Nitrofurantoin is recommended for first line prophylaxis of recurrent urinary tract infections. Despite a number of side effects it is increasingly prescribed due to its high efficacy, low cost and minimal antimicrobial resistance. Nitrofurantoin-induced immune-mediated liver injury is a particularly serious complication, resulting in both acute hepatic failure and cirrhosis with continued use. We describe the course of two patients who recently presented to our hospital in order to highlight this.
Aged, Anti-Infective Agents, Urinary/adverse effects, Biopsy, Chemical and Drug Induced Liver Injury/immunology, Female, Hepatitis, Autoimmune/immunology, Humans, Liver/pathology, Liver Cirrhosis/chemically induced, Middle Aged, Nitrofurantoin/adverse effects
Hydes, Theresa
d842d1ec-c64a-4934-a5a2-7316fea65767
Wright, Mark
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Jaynes, Eleanor
dae2d9a2-5cda-46a4-aa7e-4d04e495fe65
Nash, Kathryn
4ca77071-d810-4bc8-8f9e-a67c897c3427
5 March 2014
Hydes, Theresa
d842d1ec-c64a-4934-a5a2-7316fea65767
Wright, Mark
43325ef9-3459-4c75-b3bf-cf8d8dac2a21
Jaynes, Eleanor
dae2d9a2-5cda-46a4-aa7e-4d04e495fe65
Nash, Kathryn
4ca77071-d810-4bc8-8f9e-a67c897c3427
Hydes, Theresa, Wright, Mark, Jaynes, Eleanor and Nash, Kathryn
(2014)
Nitrofurantoin immune-mediated drug-induced liver injury: a serious complication of a commonly prescribed medication.
BMJ Case Reports, 2014.
(doi:10.1136/bcr-2013-203136).
Abstract
Nitrofurantoin is recommended for first line prophylaxis of recurrent urinary tract infections. Despite a number of side effects it is increasingly prescribed due to its high efficacy, low cost and minimal antimicrobial resistance. Nitrofurantoin-induced immune-mediated liver injury is a particularly serious complication, resulting in both acute hepatic failure and cirrhosis with continued use. We describe the course of two patients who recently presented to our hospital in order to highlight this.
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Published date: 5 March 2014
Keywords:
Aged, Anti-Infective Agents, Urinary/adverse effects, Biopsy, Chemical and Drug Induced Liver Injury/immunology, Female, Hepatitis, Autoimmune/immunology, Humans, Liver/pathology, Liver Cirrhosis/chemically induced, Middle Aged, Nitrofurantoin/adverse effects
Identifiers
Local EPrints ID: 478090
URI: http://eprints.soton.ac.uk/id/eprint/478090
ISSN: 1757-790X
PURE UUID: f2162616-f054-49e1-b4b8-f449d28db3f2
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Date deposited: 21 Jun 2023 16:54
Last modified: 17 Mar 2024 02:14
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Contributors
Author:
Theresa Hydes
Author:
Mark Wright
Author:
Eleanor Jaynes
Author:
Kathryn Nash
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