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Copper-catalyzed functionalization of 1,3-dienes: hydrofunctionalization, borofunctionalization, and difunctionalization

Copper-catalyzed functionalization of 1,3-dienes: hydrofunctionalization, borofunctionalization, and difunctionalization
Copper-catalyzed functionalization of 1,3-dienes: hydrofunctionalization, borofunctionalization, and difunctionalization

The catalytic conversion of chemical feedstocks into products of medicinal and agricultural value is a key theme across modern synthetic chemistry. As 1,3-dienes are readily available from industrial cracking processes, there is great interest in the development of sustainable methods for the functionalization of these simple molecules. Although initial developments in this field have required precious-transition-metal catalysts, there has been a push toward the use of inexpensive, nontoxic, and more abundant copper catalysts to promote functionalization. This Perspective covers the many developments in the area of copper-catalyzed functionalization of 1,3-dienes, in particular hydrofunctionalization, borofunctionalization, and difunctionalization (e.g., diamination).

1,3-dienes, asymmetric catalysis, chemical feedstocks, copper, multifunctionalization
2155-5435
1485-1499
Perry, Gregory J.P.
766e7fc8-abf3-4d1e-9949-c1b3439a2185
Jia, Tao
053b36b0-65b0-4547-a601-a2fc72ed3463
Procter, David J.
7642b405-d26f-4064-b0d2-8a1d562348b4
Perry, Gregory J.P.
766e7fc8-abf3-4d1e-9949-c1b3439a2185
Jia, Tao
053b36b0-65b0-4547-a601-a2fc72ed3463
Procter, David J.
7642b405-d26f-4064-b0d2-8a1d562348b4

Perry, Gregory J.P., Jia, Tao and Procter, David J. (2020) Copper-catalyzed functionalization of 1,3-dienes: hydrofunctionalization, borofunctionalization, and difunctionalization. ACS Catalysis, 10 (2), 1485-1499. (doi:10.1021/acscatal.9b04767).

Record type: Review

Abstract

The catalytic conversion of chemical feedstocks into products of medicinal and agricultural value is a key theme across modern synthetic chemistry. As 1,3-dienes are readily available from industrial cracking processes, there is great interest in the development of sustainable methods for the functionalization of these simple molecules. Although initial developments in this field have required precious-transition-metal catalysts, there has been a push toward the use of inexpensive, nontoxic, and more abundant copper catalysts to promote functionalization. This Perspective covers the many developments in the area of copper-catalyzed functionalization of 1,3-dienes, in particular hydrofunctionalization, borofunctionalization, and difunctionalization (e.g., diamination).

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More information

e-pub ahead of print date: 18 December 2019
Published date: 17 January 2020
Additional Information: Funding Information: We thank the EPSRC (Established Career Fellowship to D.J.P.; EP/M005062/1), the Royal Society (Newton International Fellowship to T.J.), and the University of Manchester (Lectureship to G.J.P.P.).
Keywords: 1,3-dienes, asymmetric catalysis, chemical feedstocks, copper, multifunctionalization

Identifiers

Local EPrints ID: 478105
URI: http://eprints.soton.ac.uk/id/eprint/478105
ISSN: 2155-5435
PURE UUID: 2c18e1fb-581d-4521-84a5-d653796cd79d
ORCID for Gregory J.P. Perry: ORCID iD orcid.org/0000-0001-8173-3369

Catalogue record

Date deposited: 21 Jun 2023 16:57
Last modified: 06 Jun 2024 02:17

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Contributors

Author: Gregory J.P. Perry ORCID iD
Author: Tao Jia
Author: David J. Procter

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