The role of NK cells in oncolytic viral therapy: a focus on hepatocellular carcinoma
The role of NK cells in oncolytic viral therapy: a focus on hepatocellular carcinoma
Natural killer (NK) cells have a key role in host anti-tumour immune responses via direct killing of tumour cells and promotion of adaptive immune responses. They are therefore attractive targets to promote the anti-tumour efficacy of oncolytic viral therapies. However, NK cells are also potent components of the host anti-viral immune response, and therefore have the potential for detrimental anti-viral responses, limiting the spread and persistence of oncolytic viruses. Oncolytic viruses are currently being investigated for the treatment of hepatocellular carcinoma (HCC), a leading cause of cancer-related death with a high unmet clinical need. In this review, we highlight the role of NK cells in oncolytic virus therapy, their potential for improving treatment options for patients with HCC, and discuss current and potential strategies targeting NK cells in combination with oncolytic viral therapies.
304-322
Warricker, Frazer
57296e2b-40de-43ce-bf95-007af1bae9e7
Khakoo, Salim I.
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Blunt, Matthew D.
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Warricker, Frazer
57296e2b-40de-43ce-bf95-007af1bae9e7
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Blunt, Matthew D.
b1109de3-6045-4bc3-bd77-6cf26504697d
Warricker, Frazer, Khakoo, Salim I. and Blunt, Matthew D.
(2021)
The role of NK cells in oncolytic viral therapy: a focus on hepatocellular carcinoma.
Journal of Translational Genetics and Genomics, 5, .
(doi:10.20517/jtgg.2021.27).
Abstract
Natural killer (NK) cells have a key role in host anti-tumour immune responses via direct killing of tumour cells and promotion of adaptive immune responses. They are therefore attractive targets to promote the anti-tumour efficacy of oncolytic viral therapies. However, NK cells are also potent components of the host anti-viral immune response, and therefore have the potential for detrimental anti-viral responses, limiting the spread and persistence of oncolytic viruses. Oncolytic viruses are currently being investigated for the treatment of hepatocellular carcinoma (HCC), a leading cause of cancer-related death with a high unmet clinical need. In this review, we highlight the role of NK cells in oncolytic virus therapy, their potential for improving treatment options for patients with HCC, and discuss current and potential strategies targeting NK cells in combination with oncolytic viral therapies.
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Accepted/In Press date: 3 August 2021
e-pub ahead of print date: 4 August 2021
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Local EPrints ID: 478300
URI: http://eprints.soton.ac.uk/id/eprint/478300
ISSN: 2578-5281
PURE UUID: 6134f0fd-bf39-4d02-9c64-5bfd927ccc45
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Date deposited: 27 Jun 2023 17:25
Last modified: 17 Mar 2024 03:32
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Author:
Frazer Warricker
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