Activating killer cell immunoglobulin‐like receptors: detection, function and therapeutic use
Activating killer cell immunoglobulin‐like receptors: detection, function and therapeutic use
Killer cell immunoglobulin-like receptors (KIRs) have a central role in the control of natural killer (NK) cell function. The functions of the activating KIRs, as compared to those of the inhibitory KIR, have been more difficult to define due to difficulties in antibody-mediated identification and their apparent low affinities for HLA class I. Immunogenetic studies have shown associations of activating KIRs with the outcome of autoimmune diseases, pregnancy-associated disorders, infectious diseases and cancers. Activating KIR are thus thought to have important roles in the control of natural killer cell functions and their role in disease. In this review, we discuss current knowledge on activating KIR, their ligands and, their roles in the pathogenesis and potential therapy of human diseases.
Blunt, Matthew D.
b1109de3-6045-4bc3-bd77-6cf26504697d
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
10 January 2020
Blunt, Matthew D.
b1109de3-6045-4bc3-bd77-6cf26504697d
Khakoo, Salim I.
6c16d2f5-ae80-4d9b-9100-6bfb34ad0273
Blunt, Matthew D. and Khakoo, Salim I.
(2020)
Activating killer cell immunoglobulin‐like receptors: detection, function and therapeutic use.
International Journal of Immunogenetics, 47 (1).
(doi:10.1111/iji.12461).
Abstract
Killer cell immunoglobulin-like receptors (KIRs) have a central role in the control of natural killer (NK) cell function. The functions of the activating KIRs, as compared to those of the inhibitory KIR, have been more difficult to define due to difficulties in antibody-mediated identification and their apparent low affinities for HLA class I. Immunogenetic studies have shown associations of activating KIRs with the outcome of autoimmune diseases, pregnancy-associated disorders, infectious diseases and cancers. Activating KIR are thus thought to have important roles in the control of natural killer cell functions and their role in disease. In this review, we discuss current knowledge on activating KIR, their ligands and, their roles in the pathogenesis and potential therapy of human diseases.
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Accepted/In Press date: 24 October 2019
e-pub ahead of print date: 22 November 2019
Published date: 10 January 2020
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Local EPrints ID: 478430
URI: http://eprints.soton.ac.uk/id/eprint/478430
ISSN: 1744-3121
PURE UUID: ad581f22-821f-46ea-9a45-679a32c17162
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Date deposited: 30 Jun 2023 16:51
Last modified: 17 Mar 2024 03:32
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