Antiviral potential of cathelicidins
Antiviral potential of cathelicidins
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of innate immunity has expanded over recent years, knowledge of natural host defenses against viral infections has started to offer potential for novel therapeutic strategies. An area of current research interest is in understanding the roles played by naturally occurring cationic host defense peptides, such as the cathelicidins, in these innate antiviral host defenses across different species. This research also has the potential to inform the design of novel synthetic antiviral peptide analogs and/or provide rationale for therapies aimed at boosting the natural production of these peptides. In this review, we will discuss our knowledge of the antiviral activities of cathelicidins, an important family of cationic host defense peptides, and consider the implications for novel antiviral therapeutic approaches.
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Barlow, Peter G.
18569ec3-01b1-43f2-8fb3-556f553bc821
Findlay, E.G.
43b56749-c2c1-4af9-b4c0-eaadf3360c6d
Currie, S.M.
051cd33b-755d-4e03-b391-077f1cc27c30
Davidson, D.J.
311bddd1-cfb0-49da-9f36-9e394440f278
Barlow, Peter G.
18569ec3-01b1-43f2-8fb3-556f553bc821
Findlay, E.G.
43b56749-c2c1-4af9-b4c0-eaadf3360c6d
Currie, S.M.
051cd33b-755d-4e03-b391-077f1cc27c30
Davidson, D.J.
311bddd1-cfb0-49da-9f36-9e394440f278
Barlow, Peter G., Findlay, E.G., Currie, S.M. and Davidson, D.J.
(2013)
Antiviral potential of cathelicidins.
Future Microbiology, 9 (1), .
(doi:10.2217/fmb.13.135).
Abstract
The global burden of morbidity and mortality arising from viral infections is high; however, the development of effective therapeutics has been slow. As our understanding of innate immunity has expanded over recent years, knowledge of natural host defenses against viral infections has started to offer potential for novel therapeutic strategies. An area of current research interest is in understanding the roles played by naturally occurring cationic host defense peptides, such as the cathelicidins, in these innate antiviral host defenses across different species. This research also has the potential to inform the design of novel synthetic antiviral peptide analogs and/or provide rationale for therapies aimed at boosting the natural production of these peptides. In this review, we will discuss our knowledge of the antiviral activities of cathelicidins, an important family of cationic host defense peptides, and consider the implications for novel antiviral therapeutic approaches.
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e-pub ahead of print date: 13 December 2013
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Local EPrints ID: 478805
URI: http://eprints.soton.ac.uk/id/eprint/478805
ISSN: 1746-0913
PURE UUID: ad31e181-57f6-4bf8-a3e2-58a6e680cb6e
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Date deposited: 10 Jul 2023 16:55
Last modified: 17 Mar 2024 02:36
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Contributors
Author:
Peter G. Barlow
Author:
E.G. Findlay
Author:
S.M. Currie
Author:
D.J. Davidson
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