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Non-just-right experiences are more closely related to OCD than tics in Tourette patients

Non-just-right experiences are more closely related to OCD than tics in Tourette patients
Non-just-right experiences are more closely related to OCD than tics in Tourette patients
Complex tics and obsessive or compulsive behaviour can be difficult to differentiate diagnostically. The majority of adult patients with Tourette syndrome report experiencing premonitory urges before tics. Some of these experiences have been linked to non-just-right experiences (NJRE), which are frequently reported by patients with obsessive–compulsive disorder or behaviours (OCD/OCB). We aimed to assess whether NJRE are more closely related to tics and tic-associated premonitory urges or whether they are more closely associated with OCD. A total of N = 111 patients (mean age = 34.77 + /−12.93; N = 37 female) with a confirmed diagnosis of Tourette syndrome completed the premonitory urges for tic disorders scale (PUTS), the revised non-just-right experiences scale (NJRE-QR), and questionnaires regarding their tic severity, and comorbid OCD/OCB. A multi-trait-multi-methods matrix was calculated to examine associations amongst scales measuring tic-related and OCB-related phenomena. The PUTS correlated overall higher with tic questionnaires than with OCD/OCB questionnaires. The NJRE correlated higher with OCD symptoms than with tic severity. The results indicate that non-just-right experiences are more closely associated with comorbid OCB than with tics in patients with Tourette syndrome.
2045-2322
Brandt, Valerie
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Otte, Jan-Hendrik
a17e3f58-a60a-40be-a00b-c26fc839437e
Fremer, Carolin
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Jakubovski, Ewgeni
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Müller-Vahl, Kirsten
e342bc65-d7bb-41f8-ab04-caf615f56c72
Brandt, Valerie
e41f5832-70e4-407d-8a15-85b861761656
Otte, Jan-Hendrik
a17e3f58-a60a-40be-a00b-c26fc839437e
Fremer, Carolin
ee225b6a-a823-4a9a-8db4-9cc38a363921
Jakubovski, Ewgeni
693482aa-678e-4267-af73-7805cf61ef3e
Müller-Vahl, Kirsten
e342bc65-d7bb-41f8-ab04-caf615f56c72

Brandt, Valerie, Otte, Jan-Hendrik, Fremer, Carolin, Jakubovski, Ewgeni and Müller-Vahl, Kirsten (2023) Non-just-right experiences are more closely related to OCD than tics in Tourette patients. Scientific Reports, 13 (1), [19627]. (doi:10.1038/s41598-023-37658-0).

Record type: Article

Abstract

Complex tics and obsessive or compulsive behaviour can be difficult to differentiate diagnostically. The majority of adult patients with Tourette syndrome report experiencing premonitory urges before tics. Some of these experiences have been linked to non-just-right experiences (NJRE), which are frequently reported by patients with obsessive–compulsive disorder or behaviours (OCD/OCB). We aimed to assess whether NJRE are more closely related to tics and tic-associated premonitory urges or whether they are more closely associated with OCD. A total of N = 111 patients (mean age = 34.77 + /−12.93; N = 37 female) with a confirmed diagnosis of Tourette syndrome completed the premonitory urges for tic disorders scale (PUTS), the revised non-just-right experiences scale (NJRE-QR), and questionnaires regarding their tic severity, and comorbid OCD/OCB. A multi-trait-multi-methods matrix was calculated to examine associations amongst scales measuring tic-related and OCB-related phenomena. The PUTS correlated overall higher with tic questionnaires than with OCD/OCB questionnaires. The NJRE correlated higher with OCD symptoms than with tic severity. The results indicate that non-just-right experiences are more closely associated with comorbid OCB than with tics in patients with Tourette syndrome.

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Accepted/In Press date: 27 June 2023
e-pub ahead of print date: 10 November 2023
Published date: 10 November 2023
Additional Information: Funding Information: Open Access funding enabled and organized by Projekt DEAL. This study received no funding, but the majority of patients who were included were also included in the Online-Tics study, which received funding by the German Federal Ministry of Education and Research (BMBF: 01KG1421), and by the German Tourette advocacy group “Tourette-Gesellschaft Deutschland (TGD) e.V.”, which donated EUR 600 or participated in the Canna-Tics study, which received funding by the DFG (MU 1527/2-1). Valerie Brandt received funding from the Academy of Medical Sciences. She has received royalties from Kohlhammer. Kirsten Müller-Vahl has received financial or material research support from EU (FP7-HEALTH-2011 No. 278367, FP7-PEOPLE-2012-ITN No. 316978), DFG: GZ MU 1527/3-1 and GZ MU 1527/3-2, BMBF: 01KG1421, National Institute of Mental Health (NIMH), Tourette Gesellschaft Deutschland e.V., Else-Kröner-Fresenius-Stiftung, GW pharmaceuticals, Almirall Hermal GmbH, Abide Therapeutics, and Therapix Biosiences. She has received consultant's and other honoraria from Abide Therapeutics, adjupharm, Alexion, AMP Alternative Medical Products GmbH, Ingelheim International GmbH, Bionorica Ethics GmbH, CannaMedical Pharma GmbH, Canopy Grouth, Columbia Care, CTC Communications Corp., Demecan, Enua pharma, Ethypharm GmbH, Eurox Group, Global Praxis Group Limited, Lundbeck, MCI Germany, Neuraxpharm, Sanity Group, Stadapharm GmbH, Synendos Therapeutics AG, Syqe, Tilray, and Zambon. She is an advisory/scientific board member for Alexion, Branchenverband Cannabiswirtschaft e.V. (BvCW), CannaMedical Pharma GmbH, Bionorica Ethics GmbH, CannaXan GmbH, Canopy Growth, Columbia Care, Ethypharm GmbH, IMC Germany, Leafly Deutschland GmbH, Neuraxpharm, Sanity Group, Stadapharm GmbH, Synendos Therapeutics AG, Syqe Medical Ltd., Therapix Biosciences Ltd., Tilray, von Mende Marketing GmbH, Wayland Group, and Zambon. She has received speaker’s fees from Aphria Deutschland GmbH, Almirall, Bedrocan, Camurus, CEREBRO SPAIN BIDCO S.L, Cogitando GmbH, Emalex, Eurox Deutschland GmbH, Ever pharma GmbH, GROW, Hessische Landesstelle für Suchtfragen e.V. (HLS), LIO Pharmaceuticals GmbH, Medizinischer Dienst Westfalen Lippe, Meinhardt Congress GmbH, PR Berater, Spectrum Therapeutics GmbH, Takeda GmbH, Tilray, and Wayland Group. She has received royalties from Deutsches Ärzteblatt, Der Neurologie und Psychiater, Elsevier, Medizinisch Wissenschaftliche Verlagsgesellschaft Berlin, and Kohlhammer. She served as a guest editor for Frontiers in Neurology on the research topic “The neurobiology and genetics of Gilles de la Tourette syndrome: new avenues through large-scale collaborative projects”, is an associate editor for “Cannabis and Cannabinoid Research” and an Editorial Board Member of “Medical Cannabis and Cannabinoids” und “MDPI-Reports” and a Scientific board member for “Zeitschrift für Allgemeinmedizin”. Publisher Copyright: © 2023, The Author(s).

Identifiers

Local EPrints ID: 479012
URI: http://eprints.soton.ac.uk/id/eprint/479012
ISSN: 2045-2322
PURE UUID: c7241f23-f7b8-4d1c-ac64-60698ca93dcd

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Date deposited: 17 Jul 2023 17:00
Last modified: 17 Mar 2024 07:45

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Contributors

Author: Valerie Brandt
Author: Jan-Hendrik Otte
Author: Carolin Fremer
Author: Ewgeni Jakubovski
Author: Kirsten Müller-Vahl

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