Patterns of DNA methylation of the parathyroid hormone-related protein gene in human lung carcinoma
Patterns of DNA methylation of the parathyroid hormone-related protein gene in human lung carcinoma
Humoral hypercalcaemia of malignancy often results from production of parathyroid hormone-related protein (PTHrP) by the tumour. We have investigated whether malignancy is associated with epigenetic changes in the PTHrP gene in lung. In normal and rumour tissue, there was a general background of nonmethylation in the PTHrP gene. In the 5′ region, there appeared to be increased methylation of sites upstream of the promoter, P2. The extent of methylation increased from germ line to normal tissue to tumour tissue to tumour cell Une, indicating that new methylation events in this region mark neoplastic change in lung cells.
DNA methylation, lung carcinoma, parathyroid hormone-related protein
1697-1700
Ganderton, R. H.
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Day, I. N.M.
4a300555-7eea-4f61-926e-3cdfb0fd78fe
Briggs, R. S.J.
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
September 1995
Ganderton, R. H.
0cbaa3a4-8413-4a63-b48f-e582e14a2e35
Day, I. N.M.
4a300555-7eea-4f61-926e-3cdfb0fd78fe
Briggs, R. S.J.
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Ganderton, R. H., Day, I. N.M. and Briggs, R. S.J.
(1995)
Patterns of DNA methylation of the parathyroid hormone-related protein gene in human lung carcinoma.
European Journal of Cancer, 31 (10), .
(doi:10.1016/0959-8049(95)00351-I).
Abstract
Humoral hypercalcaemia of malignancy often results from production of parathyroid hormone-related protein (PTHrP) by the tumour. We have investigated whether malignancy is associated with epigenetic changes in the PTHrP gene in lung. In normal and rumour tissue, there was a general background of nonmethylation in the PTHrP gene. In the 5′ region, there appeared to be increased methylation of sites upstream of the promoter, P2. The extent of methylation increased from germ line to normal tissue to tumour tissue to tumour cell Une, indicating that new methylation events in this region mark neoplastic change in lung cells.
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Published date: September 1995
Keywords:
DNA methylation, lung carcinoma, parathyroid hormone-related protein
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Local EPrints ID: 479042
URI: http://eprints.soton.ac.uk/id/eprint/479042
ISSN: 0959-8049
PURE UUID: 2387f35a-3683-48d8-89f2-bcd0484d30e6
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Date deposited: 19 Jul 2023 16:35
Last modified: 17 Mar 2024 03:36
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Author:
R. H. Ganderton
Author:
I. N.M. Day
Author:
R. S.J. Briggs
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