NMDA Receptor Status in Elderly Normal Individuals and Those with Alzheimer's Disease
NMDA Receptor Status in Elderly Normal Individuals and Those with Alzheimer's Disease
The status of NMDA receptors in the brains of normal aged individuals and those with Alzheimer's disease was investigated. The binding of [3H]3‐((±)‐2‐carboxypiperazin‐4‐yl)propyl phosphonic acid ([3H]CPP) to NMDA antagonist‐preferring sites on frontal and temporal cortical synaptic membranes was assessed. Binding could be resolved into two components, one of high and the other of low affinity. Pharmacologically, the two sites were qualitatively similar. Considerable intersubject variation in binding parameters was detected, but no significant differences were found between the mean values for the control and Alzheimer's disease groups. This study indicates that, when changes in receptor integrity occur in individual patients, these may be occluded because of the large variations between individuals.
50-53
Porter, R. H.P.
d977ae5c-0112-4ea7-8a8e-951b03a94649
Roberts, P. J.
01b8bb6a-a386-4f3c-a9d3-2647148e1bb8
Briggs, R. S.J.
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
September 1993
Porter, R. H.P.
d977ae5c-0112-4ea7-8a8e-951b03a94649
Roberts, P. J.
01b8bb6a-a386-4f3c-a9d3-2647148e1bb8
Briggs, R. S.J.
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Porter, R. H.P., Roberts, P. J. and Briggs, R. S.J.
(1993)
NMDA Receptor Status in Elderly Normal Individuals and Those with Alzheimer's Disease.
Annals of the New York Academy of Sciences, 695 (1), .
(doi:10.1111/j.1749-6632.1993.tb23026.x).
Abstract
The status of NMDA receptors in the brains of normal aged individuals and those with Alzheimer's disease was investigated. The binding of [3H]3‐((±)‐2‐carboxypiperazin‐4‐yl)propyl phosphonic acid ([3H]CPP) to NMDA antagonist‐preferring sites on frontal and temporal cortical synaptic membranes was assessed. Binding could be resolved into two components, one of high and the other of low affinity. Pharmacologically, the two sites were qualitatively similar. Considerable intersubject variation in binding parameters was detected, but no significant differences were found between the mean values for the control and Alzheimer's disease groups. This study indicates that, when changes in receptor integrity occur in individual patients, these may be occluded because of the large variations between individuals.
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Published date: September 1993
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Local EPrints ID: 479045
URI: http://eprints.soton.ac.uk/id/eprint/479045
ISSN: 0077-8923
PURE UUID: 4ef4e4ba-3691-4859-9a84-b7e1ef482c1d
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Date deposited: 19 Jul 2023 16:36
Last modified: 05 Jun 2024 19:54
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Author:
R. H.P. Porter
Author:
P. J. Roberts
Author:
R. S.J. Briggs
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