Muscarinic agonist receptor subtypes in aging rat brain
Muscarinic agonist receptor subtypes in aging rat brain
Whole brain homogenates from rats aged 6 months (young) and 24 months (old) showed a decline with age of the pre-synaptic cholinergic marker, choline acetyltransferase, and also of total specific binding sites for the muscarinic antagonist L(-)quinuclidinyl benzilate (L-QNB). However, neither the proportion nor the inhibition constants of high and low affinity muscarinic agonist binding sites (defined by displacement of L-QNB binding with carbachol) changed with age. These findings may be relevant to the central cholinergic deficit reported to be associated with cognitive impairment in aging man.
Aging, Brain, Muscarinic receptors
259-261
Briggs, Roger S.
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Petersen, Meryl M.
c5ef83b4-01d1-4b4d-a77e-3606892462fd
Cook, Peter J.
2083bdf4-a9bb-4386-942f-8f6974a23d71
1982
Briggs, Roger S.
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Petersen, Meryl M.
c5ef83b4-01d1-4b4d-a77e-3606892462fd
Cook, Peter J.
2083bdf4-a9bb-4386-942f-8f6974a23d71
Briggs, Roger S., Petersen, Meryl M. and Cook, Peter J.
(1982)
Muscarinic agonist receptor subtypes in aging rat brain.
Neurobiology of Aging, 3 (3), .
(doi:10.1016/0197-4580(82)90049-5).
Abstract
Whole brain homogenates from rats aged 6 months (young) and 24 months (old) showed a decline with age of the pre-synaptic cholinergic marker, choline acetyltransferase, and also of total specific binding sites for the muscarinic antagonist L(-)quinuclidinyl benzilate (L-QNB). However, neither the proportion nor the inhibition constants of high and low affinity muscarinic agonist binding sites (defined by displacement of L-QNB binding with carbachol) changed with age. These findings may be relevant to the central cholinergic deficit reported to be associated with cognitive impairment in aging man.
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Published date: 1982
Keywords:
Aging, Brain, Muscarinic receptors
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Local EPrints ID: 479059
URI: http://eprints.soton.ac.uk/id/eprint/479059
ISSN: 0197-4580
PURE UUID: 2a31d0e6-69d0-4b5a-8432-dd222d79bd2e
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Date deposited: 19 Jul 2023 16:39
Last modified: 05 Jun 2024 19:29
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Author:
Roger S. Briggs
Author:
Meryl M. Petersen
Author:
Peter J. Cook
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