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Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease

Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease
Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease

Ca2+/Cl--independentl-[3H]glutamate- and sodium-dependentd-[3H]aspartate binding assays were used to assess the integrity of N-methyl-d-aspartate (NMDA) receptors and glutamate uptake sites in a number of areas from control and Alzheimer's diseased brain. NMDA receptor densities were unchanged in all areas tested. In contrast, significant reductions in the number of glutamate terminals were seen in the hippocampus of the Alzheimer's samples. A smaller reduction was seen in the caudate nucleus but this failed to reach significance. No such reductions were seen in either the frontal or parietal cortices.

Alzheimer's disease, Glutamate, N-Methyl-d-aspartic acid receptor, Terminal
0006-8993
403-407
Cowburn, Richard
a5d9f8e5-7785-4726-9b11-9143c2c3f593
Hardy, John
bc8f3d96-0063-44a8-ad79-197befd225a6
Roberts, Peter
ab0ce3bd-e5a0-42a9-818c-ad502d7789f3
Briggs, Roger
a6b65ef0-e90c-4c07-bf5b-b70130c128b3
Cowburn, Richard
a5d9f8e5-7785-4726-9b11-9143c2c3f593
Hardy, John
bc8f3d96-0063-44a8-ad79-197befd225a6
Roberts, Peter
ab0ce3bd-e5a0-42a9-818c-ad502d7789f3
Briggs, Roger
a6b65ef0-e90c-4c07-bf5b-b70130c128b3

Cowburn, Richard, Hardy, John, Roberts, Peter and Briggs, Roger (1988) Regional distribution of pre- and postsynaptic glutamatergic function in Alzheimer's disease. Brain Research, 452 (1-2), 403-407. (doi:10.1016/0006-8993(88)90048-0).

Record type: Article

Abstract

Ca2+/Cl--independentl-[3H]glutamate- and sodium-dependentd-[3H]aspartate binding assays were used to assess the integrity of N-methyl-d-aspartate (NMDA) receptors and glutamate uptake sites in a number of areas from control and Alzheimer's diseased brain. NMDA receptor densities were unchanged in all areas tested. In contrast, significant reductions in the number of glutamate terminals were seen in the hippocampus of the Alzheimer's samples. A smaller reduction was seen in the caudate nucleus but this failed to reach significance. No such reductions were seen in either the frontal or parietal cortices.

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More information

Published date: 14 June 1988
Additional Information: Funding Information: This work was supported by grants from the Wellcome Trust (P.R and R.B) and by the Research Corporation Trust (J.H). R.C. is an MRC scholar. We thank Angela Symons for clinical follow up of the Alzheimer's cases, Prof. R.O. Weller and Drs. B.S. Wilkins and D.C. Davies for neuropathological assessments, Dr. P. Krogsgaard-Larsen (Copenhagen) for his generous gift of AMPA and Drs. M. Simpson, P. Slater and S.W. Davies for providing tissue.
Keywords: Alzheimer's disease, Glutamate, N-Methyl-d-aspartic acid receptor, Terminal

Identifiers

Local EPrints ID: 479123
URI: http://eprints.soton.ac.uk/id/eprint/479123
ISSN: 0006-8993
PURE UUID: c6f70da1-f70c-4c94-8688-03df887891d2

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Date deposited: 20 Jul 2023 16:36
Last modified: 05 Jun 2024 20:01

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Contributors

Author: Richard Cowburn
Author: John Hardy
Author: Peter Roberts
Author: Roger Briggs

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